CAS 53-85-0; 二氯苯并咪唑呋喃型核糖苷; Dichlorobenzimidazole ribofuranoside

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货号

品牌

产品名称

规格

包装、参考价格

D869702

MACKLIN

5,6-二氯苯并咪唑1-β-D-次黄嘌呤

98%

694元/100mg; 3299元/500mg;

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储存：-20°C
状态：白色到几乎白色粉末到晶体

D4292

TCI

5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside

>98.0%(HPLC)(N)

860元/100MG; 4345元/1G;

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基本信息

纯度/分析方法	>98.0%(HPLC)(N)
分子式/分子量	C₁₂H₁₂Cl₂N₂O₄ = 319.14
外观与形状(20℃)	固体
储存温度	<0℃
应避免的情况	加热
Reaxys-RN	39123
PubChem物质ID	253660379
MDL编号	MFCD00036785

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %
Melting point	220.0 to 224.0 ℃
Specific rotation [a]20/D	-66.0 ～ -68.0 deg(C=2, Pyridine)

物性(参考值)

熔点	222 ℃
比旋光度 [α]D	-67° (C=2,Pyridine)
最大吸收波长	296 nm

相关法规

RTECS#

DD7310000

447777

J&K

5,6-Dichlorobenzimidazole-1-β-D-ribofuranoside

98%

155元/10MG; 470元/50MG; 2046元/250MG;

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基本信息

分子式	C₁₂H₁₂Cl₂N₂O₄
分子量	319.14
熔点	220-224
MDL编码	MFCD00036785
Beilstein	39123
存储条件	Freezer -20℃

安全信息

防范说明	P262
WGK	3
RTECS	DD7310000
TSCA	否

J64870

Alfa Aesar

5,6-Dichlorobenzimidazole Riboside

98%

4329元/50mg; 8592元/100mg; 17795元/250mg;

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应用
Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases.

备注
Incompatible with heat and oxidizing agents.

基本信息

MDL
MFCD00036785

分子式
C₁₂H₁₂Cl₂N₂O₄

分子量
319.14

灵敏度
Store at -20°C.

形态
Powder

溶解性
Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.

Beilstein
39123

安全信息

RTECS
DD7310000

TSCA
否

287891

Sigma-Aldrich

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole-CAS 53-85-0-Calbiochem

A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC₅₀ = 6 µM).

2165.23元/50 MG;

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产品说明

一般描述

Accentuates premature termination of transcription close to the promoter. Useful for isolation of RNA sequences near promoter sites that are responsible for mRNA formation. Useful for reversible superinduction of human fibroblast cultures. Potent, ATP-competivie and specific inhibitor of casein kinase II (IC₅₀ = 6 µM). Has been used to inhibit RNA polymerase II transcription, which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes.
A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC₅₀ = 6 µM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G₁/S cell cycle arrest.

包装

50 mg in Plastic ampoule

生化/生理作用

Primary Target
casein kinase II
Reversible: no
Product competes with ATP.
Cell permeable: no

警告

Toxicity: Standard Handling (A)

制备说明

May require warming (47°C) to achieve complete dissolution.

重悬

Room temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.

其他说明

Kim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev.37, 284.
Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
Zandomeni, R., et al. 1986. J. Biol. Chem.261, 3414.
Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA79, 3167.
Stewart, M.W., et al. 1977. J. Gen. Virol.37, 221.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₂H₁₂Cl₂N₂O₄
分子量	319.14
MDL编号	MFCD00036785

产品性质

质量水平	100
测定	≥98% (TLC)
形式	solid
效能	6 μM IC₅₀
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	DMSO: 3 mg/mL ethanol: 3 mg/mL
运输	ambient
储存温度	10-30℃
InChI	1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChI key	XHSQDZXAVJRBMX-DDHJBXDOSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

D1916

Sigma-Aldrich

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

780.34元/10 MG; 2069.62元/50 MG;

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产品说明

应用

5,6-二氯苯并咪唑1-β-D-呋喃核苷用作：

抑制剂，抑制小鼠黑色素瘤细胞RNA聚合酶II
抑制人前列腺上皮细胞系细胞周期蛋白 D1 mRNA合成
抑制Jurkat细胞白介素-2基因转录

包装

10 mg in poly bottle
50 mg in glass bottle

生化/生理作用

5,6-二氯苯并咪唑1-β-D-呋喃核苷(DRB)，一种核苷类似物，可通过磷酸化 RNA聚合酶II C端结构域，使其失活，停止mRNA合成还能干扰DNA拓扑异构酶II，能调节对细胞因子的应答，通过RNA修饰阻断人免疫缺陷病毒(HIV)。它还抑制细胞周期蛋白依赖性激酶(CDK)7和9，促进白血病细胞凋亡。可作为治疗剂治疗癌症。
RNA合成抑制剂；可导致转录提前终止。 CK2(酪蛋白激酶-2)抑制剂。

特点和优势

该化合物是基因调控研究的推荐产品。点击这里发现更多精选基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。

基本信息

经验(实验)分子式	C₁₂H₁₂Cl₂N₂O₄
分子量	319.14
Beilstein	39123
MDL编号	MFCD00036785
eCl@ss	32151902
PubChem化学物质编号	24278361
NACRES	NA.77

产品性质

质量水平	200
储存温度	−20℃
SMILES string	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
InChI	1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChI key	XHSQDZXAVJRBMX-DDHJBXDOSA-N
Gene Information	human ... CSNK2A1(1457), CSNK2B(1460)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable