CAS 5291-32-7; apr-246 - �뵺�羺�ٷ��ַ

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CAS:

5291-32-7

分子式:

C₁₀H₁₇NO₃

分子量:

199.25

英文名称:

apr-246

用途:

APR-246，又名PRIMA-1MET，是一种小分子有机化合物，可以恢复肿瘤抑制功能，主要靶向突变型p53，在多种癌细胞类型中诱导细胞死亡。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

A797536

MACKLIN

APR-246 (PRIMA-1MET)

10mM in DMSO

409元/1ml;

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储存：-20°C

A873820

MACKLIN

APR-246 (PRIMA-1MET)

99%

104元/1mg; 165元/5mg; 559元/25mg; 1612元/100mg;

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储存：-20℃
状态：粉末

SML1789

Sigma-Aldrich

PRIMA-1Met

≥98% (HPLC)

1562.86元/5 MG; 6245.79元/25 MG;

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产品说明

生化/生理作用

PRIMA-1Met, also called APR-246, is converted to methylene quinuclidinone (MQ), a Michael acceptor. It interacts with p53 through the cysteine (Cys) residue. It blocks the thioredoxin reductase (TrxR1) enzyme. It is under clinical investigation and well-studied. PRIMA-1Met effect is tested on breast cancer specific gene expression.
PRIMA-1Met (APR-246) is a re-activator of mutant p53 activity. It′s the methylated, more potent derivative of PRIMA-1. PRIMA-1Met covalently modifies the core domain of mutated p53 restoring the wild-type conformation and activty of p53 in tumor cells, leading to cell cycle arrest and apoptosis. PRIMA-1Met has also been shown to increase intracellular levels of reactive oxygen species (ROS), which may contribute to its anti-tumor activity.

基本信息

经验(实验)分子式	C₁₀H₁₇NO₃
分子量	199.25
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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