CAS 529-44-2; 3,3',4',5,5',7-hexahydroxy-flavon

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货号

品牌

产品名称

规格

包装、参考价格

M794571

MACKLIN

杨梅素

10mM in DMSO

417元/1ml;

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储存：-20°C

M813619

MACKLIN

杨梅素

97%

41元/25mg; 88元/100mg; 202元/500mg; 819元/5g; 1748元/25g; 2806元/100g;

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储存：2~8°C
状态：浅黄色到黄色棕色粉末

M2131

TCI

Myricetin

>97.0%(HPLC)

815元/500MG; 4390元/5G;

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基本信息

纯度/分析方法	>97.0%(HPLC)
分子式/分子量	C₁₅H₁₀O₈ = 318.24
外观与形状(20℃)	固体
Reaxys-RN	332331
PubChem物质ID	125307777
Merck Index (14)	6332
MDL编号	MFCD00006827

技术规格

Appearance	Light yellow to Amber to Dark green powder to crystal
Purity(HPLC)	min. 97.0 area%

物性(参考值)

熔点	360 ℃
溶解性(可溶于)	二甲基甲酰胺

相关法规

RTECS#

LK8646000

154047

J&K

Myricetin

98%, 来源于杨梅

618元/25MG;

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基本信息

分子式	C₁₅H₁₀O₈
分子量	318.23
熔点	>300
MDL编码	MFCD00006827
Beilstein	332331
Merck	14,6332
EINECS 编号	208-463-2

安全信息

防范说明	P262
WGK	3
RTECS	LK8646000

907766

J&K

Myricetin

98%, 来源于杨梅

150元/20MG;

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基本信息

分子式	C₁₅H₁₀O₈
分子量	318.23
熔点	>300
MDL编码	MFCD00006827
Beilstein	332331
Merck	14,6332
EINECS 编号	208-463-2

安全信息

防范说明	P262
WGK	3
RTECS	LK8646000

C15159

Alfa Aesar

Myricetin

95%

1469元/25mg;

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基本信息

Ref#
15159

MDL
6827

分子式
C15 H10 O8

分子量
318.23

形态
Crystalline solid

M6760

Sigma-Aldrich

Myricetin

≥96.0%, crystalline

912.78元/10 MG; 1612.96元/25 MG;

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产品说明

应用

杨梅黄素用于：

探讨其对终产物 (AGE)-牛血清白蛋白介导的丝裂原活化蛋白激酶 (ERK1) 磷酸化的影响
作为使用高效液相色谱法 (HPLC) 定量测定 noni 植物提取物中酚类物质的标准品
作为使用超高效液相色谱(UHPLC)表征木芙蓉酚类化合物的标准品

生化/生理作用

杨梅黄素是一种天然存在的黄酮醇，具有抗氧化属性。它显示出中等的膜渗透性，并且在升高的 pH 值下它迅速降解。杨梅黄素是可食用植物中存在的主要类黄酮之一，具有抗癌和抗突变功能。它由两个苯环 A 和 B 组成。环 B 嵌入核苷酸铆接并抑制细菌 DNA 合成。杨梅素在糖尿病大鼠中引起对叔丁基过氧化氢(t-BHP)产生的氧化应激的保护作用，并改善谷胱甘肽过氧化物酶(GPx)和黄嘌呤氧化酶(XO)酶活性。它还可以降低低密度脂蛋白的糖化。

其他说明

由Scripps Center for Metabolomics独立生成的串联质谱数据可以以PDF格式查看或下载。M6760.pdf供试代谢产物见 Scripps Center for Metabolomics METLIN 代谢产物数据库。若要了解更多信息，请访问sigma.com/ metlin。

基本信息

经验(实验)分子式	C₁₅H₁₀O₈
分子量	318.24
Beilstein	332331
EC 号	208-463-2
MDL编号	MFCD00006827
PubChem化学物质编号	24278566
NACRES	NA.77

产品性质

质量水平	100
测定	≥96.0%
形式	crystalline
mp	>300 ℃ (lit.)
溶解性	absolute ethanol: 10 mg/mL, clear to slightly hazy, yellow to very deep greenish-yellow
SMILES string	Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3
InChI	1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
InChI key	IKMDFBPHZNJCSN-UHFFFAOYSA-N
Gene Information	human ... CYP1A2(1544) mouse ... Hexa(15211) rat ... Il4(287287), Tnf(24835)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

70050

Sigma-Aldrich

Myricetin

≥96.0% (HPLC)

1768.83元/25 MG; 4942.45元/100 MG;

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产品说明

一般描述

杨梅酮(MYR)一种天然的聚羟基黄烷醇化合物，最早从杨梅树中分离出来。

应用

杨梅酮可用于：

研究其作为抗氧化剂对大鼠噪声性听力损失(NIHL)的预防作用
用作黄酮类化合物测试波旁病毒(BRBV)的抗病毒活性和依赖于 RNA 的 RNA 聚合酶(RdRP)的抑制作用
研究其对变形链球菌和白色念珠菌生物膜的治疗效果
作为刺柏属植物中酚类化合物定量分析的参考标准

生化/生理作用

杨梅酮通过调节多信号通路发挥抗氧化和抗炎作用。此外，它还具有抗糖尿病和保肝作用。杨梅酮可强烈抑制酵母 α-葡萄糖苷酶、乙二醛酶 I 体外、和牛乳黄嘌呤氧化酶。此外，它还可促进 DNA 与拓扑异构酶 I 和 II 之间形成络合物，从而可能在癌症化疗中发挥价值。此外，杨梅酮还具有多种营养保健价值和疗效。

基本信息

经验(实验)分子式	C₁₅H₁₀O₈
分子量	318.24
Beilstein	332331
EC 号	208-463-2
MDL编号	MFCD00006827
PubChem化学物质编号	57652239
NACRES	NA.77

产品性质

测定	≥96.0% (HPLC)
形式	powder
mp	≥300 ℃ >300 ℃ (lit.)
溶解性	ethanol: 10 mg/mL, clear to very faintly turbid, yellow to very deep greenish-yellow
SMILES string	Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3
InChI	1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
InChI key	IKMDFBPHZNJCSN-UHFFFAOYSA-N
Gene Information	human ... CYP1A2(1544) mouse ... Hexa(15211) rat ... Il4(287287), Tnf(24835)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

05390590

Myricetin

primary reference standard

5355.15元/10 MG;

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产品说明

一般描述

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

应用

草药产品分析的标准品。

基本信息

经验(实验)分子式	C₁₅H₁₀O₈
分子量	318.24
Beilstein	332331
EC 号	208-463-2
MDL编号	MFCD00006827
PubChem化学物质编号	329748055
NACRES	NA.24

产品性质

等级	primary reference standard
保质期	limited shelf life, expiry date on the label
manufacturer/tradename	HWI
mp	>300 ℃ (lit.)
application(s)	food and beverages
储存温度	−20℃
SMILES string	Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3
InChI	1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
InChI key	IKMDFBPHZNJCSN-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PHL89252

Myricetin

phyproof^® Reference Substance

3997.36元/20 MG;

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产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式	C₁₅H₁₀O₈
分子量	318.24
Beilstein	332331
MDL编号	MFCD00006827

产品性质

等级	primary reference standard
产品线	phyproof^® Reference Substance
测定	≥95.0% (HPLC)
形式	solid
manufacturer/tradename	PhytoLab
mp	>300 ℃ (lit.)
SMILES string	Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3
InChI	1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
InChI key	IKMDFBPHZNJCSN-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

72576

Supelco

Myricetin

analytical standard

2804.03元/10 MG;

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产品说明

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

基本信息

经验(实验)分子式	C₁₅H₁₀O₈
分子量	318.24
Beilstein	332331
EC 号	208-463-2
MDL编号	MFCD00006827
PubChem化学物质编号	329764181
NACRES	NA.24

产品性质

质量水平	100
等级	analytical standard
测定	≥98% (HPLC)
保质期	limited shelf life, expiry date on the label
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	>300 ℃ (lit.)
application(s)	food and beverages
格式	neat
储存温度	2-8℃
SMILES string	Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3
InChI	1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
InChI key	IKMDFBPHZNJCSN-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

476275

Sigma-Aldrich

Myricetin-CAS 529-44-2-Calbiochem

A cell-permeable flavanoid that displays anti-inflammatory, anti-diabetic and anti-cancer properties.

1560.15元/25 MG;

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产品说明

一般描述

A cell-permeable flavanoid that displays anti-inflammatory, anti-diabetic and anti-cancer properties. Acts as a non-ATP competitive MEK1 inhibitor (IC₅₀<3 µM), and ATP-competitive inhibitors of CKI, CKII, IR, MLCK, PKA and PKC (K_i = 9.0 µM, 0.6 µM, 2.6 µM, 1.7 µM, 27.5 µM and 12.1 µM, respectively) and PI 3-Kα and PIM-1 (IC₅₀ = 1.8 µM and 0.78 µM). Reported to inhibit the activities of phosphodiesterase 1-4 (IC₅₀<40 µM) and MMP-2 (IC₅₀<24 µM in several colorectal carcinoma cells), and block TNFα-mediated NF-κB signaling (at 50 µM in ECV304 cells) and insulin-stimulated glucose transport (K_i ~ 33.5 µM in rat adipocytes). Further, induce apoptosis in HL-60 leukemia cells with an IC₅₀ of 43 µM.
A cell-permeable flavanoid that displays anti-inflammatory, anti-diabetic and anti-cancer properties. Acts as a non-ATP competitive MEK1 inhibitor (IC₅₀<3 µM), and ATP-competitive inhibitors of CKI, CKII, IR, MLCK, PKA and PKC (K_i = 9.0 µM, 0.6 µM, 2.6 µM, 1.7 µM, 27.5 µM and 12.1 µM, respectively) and PI 3-Kα and PIM-1 (IC₅₀ = 1.8 µM and 0.78 µM). Reported to inhibit the activities of phosphodiesterase 1-4 (IC₅₀<40 µM) and MMP-2 (IC₅₀<24 µM in several colorectal carcinoma cells), and block TNFα-mediated NF-κB signaling (at 50 µM in ECV304 cells) and insulin-stimulated glucose transport (K_i = ~ 33.5 µM in rat adipocytes). Further, induce apoptosis in HL-60 leukemia cells with an IC₅₀ of 43 µM.

包装

25 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Lee, K.W., et al. 2007. Carcinogenesis28, 1918.
Holder, S., et al. 2007. Mol. Cancer Ther.6, 163.
Strobel, P., et al. 2005. Biochem. J.386, 471.
Ko, C.H., et al. 2005. Mol. Cancer Ther.4, 281.
Ko, C.H., et al. 2005. Biochem. Pharmacol.69, 913.
Ko, W.C., et al. 2004. Biochem. Pharmacol.68, 2087.
Walker, E.H., et al. 2000. Mol. Cell6, 909.
Agullo, G., et al. 1997. Biochem. Pharmacol.53, 1649.
Hagiwara, M., et al. 1988. Biochem. Pharmacol.37, 2987.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₅H₁₀O₈
分子量	318.24
MDL编号	MFCD00006827

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	yellow-brown
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
InChI key	IKMDFBPHZNJCSN-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

239118

Fluorochem

3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one

95%

220元/250mg; 396元/1g; 1122元/5g; 1892元/10g;

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基本信息

CAS Number	529-44-2
MDL Number	MFCD00006827

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.