| CAS: | 522650-83-5 | |
| 分子式: | C22H23N5O2S | |
| 分子量: | 421.52 | |
| 英文名称: |
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| 用途: | SW044248是一种新型非常规的TOP1抑制剂, 对非小细胞肺癌细胞具有选择性毒性。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||
| S795838 | MACKLIN | SW-044248 | 10mM in DMSO | 684元/1ml; | 咨询 | ||||||||
储存：-20°C | |||||||||||||
| S861014 | MACKLIN | SW-044248 | >98% | 807元/10mg; 1877元/25mg; | 咨询 | ||||||||
储存：-20℃ 状态：浅黄色固体 折射率：light yellow solid | |||||||||||||
| 2286646 | J&K | SW044248 | 98%, 一种非典型的拓扑异构酶 I (topoisomerase I) 抑制剂 | 855元/5MG; 1473元/10MG; | 咨询 | ||||||||
基本信息
产品描述 SW-044248是非经典的Topo1抑制剂，对非小细胞肺癌细胞具有选择性毒性作用。 靶点（IC50 & Targe） Topo I 体外研究 SW044248 is selectively toxic for some NSCLC cell lines. SW044248 rapidly inhibits transcription, translation and DNA synthesis in sensitive cells but not insensitive cells. The acute transcriptional response to SW044248 correlates with the response to agents that cause DNA damage[1]. 细胞实验 Cell lines: NSCLC cell lines Concentrations: -- Incubation Time: 96 h Method:Cell viability assay (Only for Reference) 参考文献 [1] Iryna O. Zubovych, et al. Mol Cancer Ther. 2016, 15(1): 23-36. | |||||||||||||
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