| CAS: | 522606-67-3 | ||||
| 分子式: | C17H21N7 | ||||
| 分子量: | 323.4 | ||||
| 英文名称: |
| ||||
| 用途: | SID3712249 (MIR-544 Inhibitor 1) 是微小RNA-544 (miR-544) 的生物合成抑制剂。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||
| S878652 | MACKLIN | SID 3712249 | ≥98% | 921元/5mg; 1570元/10mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||||||||||||||
| SML1518 | Sigma-Aldrich | SID 3712249 | ≥95% (HPLC) | 1117.23元/5 MG; 4498.97元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir. 其他说明 light sensitive 基本信息
产品性质
安全信息
| |||||||||||||||||||||||||||||||||||||||||||||
m.cnreagent.com