CAS 520-36-5; 芹菜素; 4',5,7-trihydroxy-flavon

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货号

品牌

产品名称

规格

包装、参考价格

A800499

MACKLIN

芹菜素

分析对照品

152元/20mg;

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储存：-20°C
状态：黄色粉末

A828124

MACKLIN

芹菜素

≥95% (HPLC)

30元/1g; 89元/5g; 370元/25g; 1399元/100g;

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储存：-20°C

A823203

MACKLIN

芹菜素

≥97% (HPLC)

32元/1g; 102元/5g; 400元/25g; 1578元/100g;

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储存：-20°C
状态：黄色粉末或晶体

A800500

MACKLIN

芹菜素

≥98.0% (HPLC)

30元/25mg; 35元/100mg; 46元/500mg; 78元/1g; 160元/5g; 508元/25g; 1822元/100g;

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储存：-20°C
状态：黄色到黄绿色粉末

A1514

TCI

Apigenin

>98.0%(HPLC)

1400元/100MG;

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基本信息

纯度/分析方法	>98.0%(HPLC)
分子式/分子量	C₁₅H₁₀O₅ = 270.24
外观与形状(20℃)	固体
Reaxys-RN	262620
PubChem物质ID	87562965
Merck Index (14)	730
MDL编号	MFCD00006831

技术规格

Appearance	Light yellow to Brown powder to crystal
Purity(HPLC)	min. 98.0 area%

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

相关法规

RTECS#

LK9276000

470737

J&K

Apigenin

98%

60元/5MG; 63元/25MG; 66元/100MG; 70元/500MG;

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基本信息

分子式	C₁₅H₁₀O₅
分子量	270.24
熔点	>300
MDL编码	MFCD00006831
Beilstein	262620
Merck	14,730
EINECS 编号	208-292-3
存储条件	Freezer -20℃

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	3
RTECS	LK9276000

952027

J&K

Apigenin

来源于芹菜, 有效含量≥90%, 可溯源至中检院标准品

228元/20MG;

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基本信息

分子式	C₁₅H₁₀O₅
分子量	270.24
MDL编码	MFCD00006831

L15041

Alfa Aesar

4',5,7-Trihydroxyflavone

97%

1384元/25mg; 3853元/100mg;

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应用
4',5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with and strong oxidizing agents.

基本信息

MDL
MFCD00006831

EINECS
208-292-3

分子式
C₁₅H₁₀O₅

分子量
270.24

熔点
ca 315° dec.

灵敏度
Keep Cold.

形态
Powder

溶解性
Soluble in dimethyl sulfoxide (27 mg/ml) or 1M potassium hydroxide (50mg/ml).

Beilstein
262620

Merck
14,730

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

RTECS
LK9276000

TSCA
否

178278

Sigma-Aldrich

Apigenin-CAS 520-36-5-Calbiochem

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).

773.29元/5 MG;

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产品说明

一般描述

A plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44^mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G₂/M arrest and to induce morphological differentiation.
Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G₂/M arrest and induces morphological differentiation.

包装

5 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
Primary Target
MAP kinase
Cell permeable: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.

其他说明

Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun.212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett.87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun.204, 578.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
MDL编号	MFCD00006831

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	crystalline solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	yellow
溶解性	hot ethanol: 1 mg/mL DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

SMB00702

Sigma-Aldrich

Apigenin

≥97% (TLC), from citrus

559.88元/5 MG; 1652.94元/25 MG; 5078.82元/100 MG;

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产品说明

一般描述

Apigenin (ApI) is also called as 5,7,4′-trihydroxyflavone. It is a natural compound, found in several fruits and herbs, like, oranges, onions and parsley.

包装

5 mg in glass bottle
25, 100 mg in poly bottle

生化/生理作用

Apigenin (ApI) blocks the development of thyroid cancer cells by attenuating epidermal growth factor receptor (EGF-R) tyrosine phosphorylation and phosphorylation of ERK mitogen-activated protein (MAP) kinase. Apigenin participates in the modulation of different signaling cascades. It possesses several functions such as, antiapoptosis, anti-inflammation, anticancer, antibacterial and antioxidant effects.
一种植物类黄酮，研究发现它通过在G₂/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
EC 号	208-292-3
MDL编号	MFCD00006831
NACRES	NA.79

产品性质

质量水平	200
测定	≥97% (TLC)
形式	powder
mp	>300 ℃ (lit.)
溶解性	DMSO: 27 mg/mL 1 M KOH: 50 mg/mL
储存温度	−20℃
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N
Gene Information	human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931) mouse ... Hexa(15211) rat ... Adora1(29290), Adora2a(25369), IL4(287287), Tnf(24835)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

10798

Sigma-Aldrich

Apigenin

≥95.0% (HPLC)

1430.82元/25 MG; 3507.18元/100 MG;

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产品说明

一般描述

Apigenin is a 270 Da flavonoid, which belongs to the flavone group of glycosides. It is synthesized by a wide variety of plants including cereals, grains, tea and oranges.

应用

芹菜素已被用作校准标准，结合高效液相色谱(HPLC)和二极管阵列检测(DAD)对山柳菊、枯柏树进行定量。它已用于研究对人肾上腺皮质H295R细胞激素分泌的影响。

生化/生理作用

芹菜素是一种二级药物，肠渗透性强。它具有抗氧化、抗炎和抗肿瘤的功能。它是分化簇38 (CD30)核苷酸腺嘌呤二核苷酸(NAD⁺)核苷酶的有效抑制剂，可用于抑制CD30介导的代谢综合征。
一种植物类黄酮，研究发现它通过在G₂/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

其他说明

人雌激素合成酶抑制剂

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
EC 号	208-292-3
MDL编号	MFCD00006831
PubChem化学物质编号	57646817
NACRES	NA.77

产品性质

质量水平	100
测定	≥95.0% (HPLC)
杂质	~2% water
mp	>300 ℃ (lit.)
储存温度	−20℃
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N
Gene Information	human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931) mouse ... Hexa(15211) rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

42251

Supelco

Apigenin

analytical standard

4040.52元/10 MG;

咨询

产品说明

一般描述

黄酮类化合物属于多酚类化合物。在抑制肿瘤生长和化学预防等生物活性中起关键作用。芹菜素是一种植物类黄酮，多用于抑制鸟氨酸脱羧酶活性和皮肤肿瘤。

应用

LC-ESI-MS/MS 可作为内标物，用于测定大鼠血液和尿液中的飞燕草苷及其代谢产物。
有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务。

生化/生理作用

一种植物类黄酮，研究发现它通过在G₂/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
EC 号	208-292-3
MDL编号	MFCD00006831
PubChem化学物质编号	329756029
NACRES	NA.24

产品性质

质量水平	100
等级	analytical standard
测定	≥99% (HPLC)
保质期	limited shelf life, expiry date on the label
technique(s)	HPLC: suitable gas chromatography (GC): suitable
mp	>300 ℃ (lit.)
application(s)	food and beverages
格式	neat
储存温度	2-8℃
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

PHR2198

Supelco

Apigenin

Pharmaceutical Secondary Standard; Certified Reference Material

1909.73元/75 MG;

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产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC2233 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
MDL编号	MFCD00006831

产品性质

等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
包装	pkg of 75 mg
mp	>300 ℃ (lit.)
格式	neat
药典可追溯性	traceable to USP 1040683
储存温度	-10 to -25℃
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PHL89159

Apigenin

phyproof^® Reference Substance

3997.36元/25 MG;

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产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化/生理作用

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
MDL编号	MFCD00006831

产品性质

等级	primary reference standard
产品线	phyproof^® Reference Substance
测定	≥95.0% (HPLC)
形式	powder
manufacturer/tradename	PhytoLab
mp	>300 ℃ (lit.)
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3

1040683

USP

Apigenin

United States Pharmacopeia (USP) Reference Standard

3889.96元/30 MG;

咨询

产品说明

一般描述

应用

It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats.

生化/生理作用

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
MDL编号	MFCD00006831
PubChem化学物质编号	329749048
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
mp	>300 ℃ (lit.)
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	−20℃
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

01760595

Apigenin

primary reference standard

5844.83元/10 MG;

咨询

产品说明

一般描述

Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor.
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

应用

It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats.

生化/生理作用

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
EC 号	208-292-3
MDL编号	MFCD00006831
PubChem化学物质编号	329747355
NACRES	NA.24

产品性质

等级	primary reference standard
保质期	limited shelf life, expiry date on the label
manufacturer/tradename	HWI
mp	>300 ℃ (lit.)
application(s)	food and beverages
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

M01289

Fluorochem

4,5,7-Trihydroxyflavone

>95%

242元/1g; 726元/5g; 1144元/10g; 2420元/25g;

咨询

基本信息

CAS Number	520-36-5
MDL Number	MFCD00006831
Melting Point	345-350℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .