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CAS: 515141-51-2
分子式: C25H24ClN3O3S
分子量: 481.995
英文名称: 
gw-803430
6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3h-thieno[3,2-d]pyrimidin-4-one
gw-803430a
gw-3430
用途: A potent, specific, orally active melanin concentrating hormone receptor 1 (MCHR1)  inhibitor with kI of 3.8 nM, >100-fold selectivity over a battery of GPCRs, ion channels and enzymes.
推荐供应商
货号品牌产品名称规格包装、参考价格
G910267MACKLINGW 80343098%1104元/5mg;   1514元/10mg;   咨询
储存:-20°C,密闭,干燥
SML0230Sigma-AldrichGW-803430≥98% (HPLC)1628元/5 MG;   咨询

产品说明

应用

GW-803430 may be used in MCHR1-mediated cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

GW-803430 antagonizes central MCHR1 and produces anxiolytic, anti-depressant and anti-obesity effects in rats and mice. It also controls the alcohol-seeking behavior in rats and is a promising treatment for alcohol use-related disorders.
GW-803430 is a centraly active and selective melanin-concentrating hormone receptor (MCHR) 1 antagonist

特点和优势

This compound is featured on the Melanin-Concentrating Hormone Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C25H24ClN3O3S
分子量481.99
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: ≥4 mg/mL at warmed to 60 ℃
创始人GlaxoSmithKline
储存温度2-8℃

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P301 + P312 + P330 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9
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