CAS 504-88-1; 3-NPA; 3-nitro-propionic aci

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货号

品牌

产品名称

规格

包装、参考价格

N814662

MACKLIN

3-硝基丙酸

95%

150元/250mg; 280元/500mg; 493元/1g; 1914元/5g;

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储存：2-8°C
状态：无色到浅黄色粉末

N5636

Sigma-Aldrich

3-Nitropropionic acid

≥97%

1237.75元/1 G; 5956.22元/10 G;

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产品说明

应用

3-硝基丙酸已用于：

建立大鼠的多系统萎缩-帕金森症(MSA-P)模型，评估其对胚胎纹状体和中脑移植物的影响
注入大鼠的黑质纹状体多巴胺能通路，研究其对多巴胺系统的特定作用
作为LUHMES神经元和细胞系的琥珀酸脱氢酶(SDH)抑制剂

包装

10 g in poly bottle

生化/生理作用

内耳施用3-硝基丙酸(3-NP)会导致感音神经性听力损失。它可作为线粒体复合体II的不可逆抑制剂。
兴奋性神经毒素，证明可引起类似于 Huntington 疾病的脑损伤。

基本信息

线性分子式	O₂N(CH₂)₂CO₂H
分子量	119.08
Beilstein	1759889
EC 号	208-003-0
MDL编号	MFCD00007406
PubChem化学物质编号	24278593
NACRES	NA.77

产品性质

质量水平	100
生物来源	synthetic
测定	≥97%
形式	powder or crystals
颜色	white to light yellow
mp	68-70 ℃ (lit.)
溶解性	alcohol: may be light yellow 100 mg/mL
储存温度	2-8℃
SMILES string	OC(CC[N+]([O-])=O)=O
InChI	1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
InChI key	WBLZUCOIBUDNBV-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

N22908

Sigma-Aldrich

3-Nitropropionic acid

97%

1944.04元/10 G;

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产品说明

生化/生理作用

兴奋性神经毒素，证明可引起类似于 Huntington 疾病的脑损伤。

基本信息

线性分子式	O₂N(CH₂)₂CO₂H
分子量	119.08
Beilstein	1759889
EC 号	208-003-0
MDL编号	MFCD00007406
PubChem化学物质编号	329818412
NACRES	NA.22

产品性质

质量水平	100
测定	97%
形式	crystals
mp	68-70 ℃ (lit.)
储存温度	2-8℃
SMILES string	OC(CC[N+]([O-])=O)=O
InChI	1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
InChI key	WBLZUCOIBUDNBV-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

164603

Sigma-Aldrich

3-Nitropropionic acid-CAS 504-88-1-Calbiochem

A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.

1164.01元/50 MG;

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产品说明

一般描述

A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.

包装

50 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Toxic (F)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Beal, M., et al. 1993, J. Neurosci.13, 4181.
Pang, Z., et al. 1997, J. Neuroscience17, 3064.
Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
Kim, G. W., et al. 2003, J. Neurosci.23, 8733.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₃H₅NO₄
分子量	119.08
MDL编号	MFCD00007406

产品性质

质量水平	100
测定	≥98% (NMR)
形式	powder
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	light yellow
溶解性	ethanol: 100 mg/mL DMSO: soluble
运输	ambient
储存温度	2-8℃
InChI	1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
InChI key	WBLZUCOIBUDNBV-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

035948

Fluorochem

3-Nitropropionic acid

98+%

462元/1g; 2134元/5g; 10384元/25g;

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基本信息

CAS Number	504-88-1
MDL Number	MFCD00007406
Boiling Point	222.3℃
Melting Point	62℃-67℃
Density	1.6731

安全信息

图形或危害标志
危险性说明	H301: Toxic if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.