基本信息

技术规格

物性(参考值)

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

相关法规

基本信息

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	3
RTECS	LK9275210

基本信息

应用
3',4',5,7-Tetrahydroxyflavone is used as an apoptosis inducer.

备注
Incompatible with strong oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8?°C.

基本信息

MDL
MFCD00017309

EINECS
207-741-0

分子式
C₁₅H₁₀O₆

分子量
286.24

熔点
>300°

灵敏度
Ambient temperatures.

溶解性
Soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (～5 mg/ml), dimethyl sulfoxide (7 mg/ml), 1eq. Sodium hydroxide (5 mM), dimethylformamide (～20 mg/ml), water (1 mg/ml) at 25°C and methanol.

Beilstein
292084

Merck
14,5614

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

RTECS
LK9275210

TSCA
否

产品说明

一般描述

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
rat liver cytosolic glutathione S-transferase activity
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

其他说明

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

产品说明

一般描述

木犀草素(3′,4′,5′,7′-四羟黄酮)是一种多酚化合物，属于黄酮类。木犀草素常见于芹菜、青椒和洋甘菊茶等植物中。木犀草素是存在于Hieracium pannosum Boiss的花提取物以及Dracocephalum kotschyi的地上部分中的主要黄酮类化合物之一，可促进植物的抗氧化能力。木犀草素具有抗氧化性和抗炎活性， 并且主要通过细胞凋亡发挥抗肿瘤作用。木犀草素通过下调蛋白激酶B(Akt)途径引起半胱天冬酶介导的细胞凋亡，从而发挥其凋亡活性。木犀草素还能使癌细胞对治疗剂再次敏感。木犀草素可调节炎症基因，并减少一氧化氮和炎性细胞因子的产生。木犀草素的抗炎活性，使其成为阿尔茨海默病等神经退行性疾病的潜在治疗剂。在植物中，木犀草素可诱导结瘤蛋白F(nodF)基因表达。

应用

木犀草素已可用于：

• 诱导和阐明肾细胞癌786-O细胞的凋亡途径
• 作为M9基本培养基中的添加剂，诱导nodF基因表达
• 作为参考标准品，通过使用反相高效液相色谱法-二极管阵列检测器(RP-HPLC-DAD)对木犀草素进行定性和定量分析
• 作为β-半乳糖苷酶测定的反应补充剂
• 通过测定抗炎介质产生以及测定细胞活力和细胞毒性，阐明木犀草素在伪狂犬病病毒感染的RAW264.7细胞系中的抗炎作用

生化/生理作用

羟基黄酮衍生物，一种强抗氧化剂和自由基清除剂。被认为可能通过抑制脂肪酸合成酶活性而发挥预防癌症的作用。

基本信息

产品性质

安全信息

产品说明

一般描述

木犀草素是一种普遍存在于蔬菜中的天然黄酮类物质。它可能具有多种生物学属性，如针对皮肤乳头状瘤具有抗肿瘤活性。

应用

有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

基本信息

产品性质

安全信息

产品说明

一般描述

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

应用

Reference Standard in the analysis of herbal medicinal products

基本信息

产品性质

安全信息

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

产品性质

安全信息

基本信息

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .