| CAS: | 486993-62-8 | |||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||
| SML2019 | Sigma-Aldrich | DS44170716 | ≥98% (HPLC) | 1168.11元/5 MG; 4730.28元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 DS44170716 is an inhibitor of Ca2+-induced mitochondrial permeability transition. It has a different mechanism of action from cyclosporin A that is not dependent on PPIF, a peptidyl-prolyl cis-trans isomerase associated with the mitochondrial permeability transition pore (MPTP). Instead DS44170716 blocks Ca2+ flux into the mitochondria by decreasing mitochondrial membrane potential and inhibits enzyme activities of mitochondrial respiratory chain complex III, IV and V. It showed a similar potent protective effect against Ca2+-induced death in human liver cells as Cyclosporin A. 基本信息
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