| CAS: | 479683-64-2 | ||
| 分子式: | C15H17ClN4O | ||
| 分子量: | 304.77 | ||
| 英文名称: |
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| 用途: | CP-809101是5-HT2C受体激动剂，对人5-HT2C，5-HT2B和5-HT2A受体的pEC50分别为9.96，7.19和6.81。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||
| C878895 | MACKLIN | CP-809101 | 98% | 978元/10mg; 4191元/50mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||||||||||||
| PZ0378 | Sigma-Aldrich | CP-809,101 fumarate | ≥98% (HPLC) | 1387.85元/5 MG; 5586.13元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 CP-809,101 is a potent and high-affinity 5-hydroxytryptamine receptor 2C (5-HT2C) full agonist with only weaker partial agonist activity toward 5-HT2A & 5-HT2B (cellular Ca2+ mobilization EC50 in nM/efficiency = 0.11/93% and 0.06/97% with human and rat 5-HT2C, respectively; 153/67%/human 5HT2A, 65.3/57%/human 5HT2B, 119/79%/rat 5HT2A) and much reduced or little affinity toward other receptors, ion channels and uptake sites tested. CP-809,101 exhibits antipsychotic efficacy in reducing conditioned avoidance response/CAR (ED50 = 4.8 mg/kg s.c.) and locomotor activity (ED50 in mg/kg via s.c. = 2/rats, 1/mice; no effect up to 10 mg/kg in 5-HT2C-knockout mice), while oral administration is reported to suppress spontaneous and nocturnal food intake as well as fasting-induced refeeding in rats (∼8% and ∼24% reduction of cumulative food intake and body weight in 4 days, respectively; 30 mg/kg/day p.o.). 法律信息 Sold for research purposes under agreement from Pfizer Inc. 基本信息
产品性质
安全信息
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