基本信息

技术规格

物性(参考值)

产品说明

一般描述

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC₅₀ = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC₅₀ >16 µM).
A cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC₅₀ = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC₅₀ >16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158).

包装

2 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Secondary Target
ALK 5 auto phosphorylation (IC₅₀ = 4 nM)
Product competes with ATP.
Primary Target
ALKS binding

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Gellibert, F., et al. 2004. J. Med. Chem.47, 4494.
Ichida, J. K., et al. 2009. 5, 491.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

产品说明

应用

RepSox已被用于转化生长因子β激酶1型受体(ALK5)的抑制剂。此外，还可用于基本培养基成分，以培养人类多能干细胞。

包装

5, 25 mg in glass bottle

生化/生理作用

RepSox 抑制 TGF-β 受体信号。逆转录病毒转导 Sox2、Oct4 和 Klf4 基因导致体细胞直接重编程为诱导多能干细胞 (iPSC)。
RepSox通过抑制SMAD族成员3 (Smad3)和c-Jun n -端激酶(JNK)途径/激活蛋白质1 (AP-1)途径，抑制破骨细胞分化、骨组织吸收和卵巢切除术(OVX)诱导的骨质疏松症(OP)。

基本信息

产品性质

安全信息

基本信息