| CAS: | 445479-97-0 | ||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||
| 227016 | Sigma-Aldrich | CCR2 Antagonist-CAS 445479-97-0-Calbiochem | The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2. | 3124.36元/5 MG; | 咨询 | ||||||||||||||||||||||||||||||||
产品说明 一般描述 A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding. 包装 5 mg in Plastic ampoule 警告 Toxicity: Standard Handling (A) 制备说明 Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization. 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Cherney, R.J., et al. 2008. J. Med. Chem.51, 721. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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