CAS 444288-86-2; cc-3060 - �뵺�羺�ٷ��ַ

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CAS:

444288-86-2

英文名称:

cc-3060

4-[(benzofuran-2-ylmethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

4-[(2-benzofuranylmethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1h-isoindole-1,3(2h)-dione

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货号

品牌

产品名称

规格

包装、参考价格

SML3053

Sigma-Aldrich

CC-3060

≥98% (HPLC)

1156.54元/5 MG; 4672.46元/25 MG;

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产品说明

生化/生理作用

CC-3060 is a cell-permeable pomalidomide analog that acts as a potent, efficacious and dose-dependent promoter of CRL4CRBN-mediated ZBTB16 (Promyelocytic Leukemia Zinc Finger protein or PLZF) proteasomal degradation (DC50 = 0.47 nM and a ymin of 28 in HT-1080 ZBTB16-ePL cells). CC-3060 is shown to directly interact with the C2H2 ZnF1 domain, form a ternary complex with CRBN/ZBTB16 and stimulate ZBTB16-RARα robust degradation (Ymin of 20 in RAR?-ZBTB16-ePL cells). Also facilitates degradation of CRBN neosubstrates IKZF1, ZFP91, and ZNF276 with no effect on GSPT1 and CSNK1A1.

基本信息

经验(实验)分子式	C₂₂H₁₇N₃O₅
分子量	403.39

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC4=CC5=C(C=CC=C5)O4)=CC=C3)=O)=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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