| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| T797772 | MACKLIN | 三氟拉嗪二盐酸盐 | 10mM in DMSO | 520元/1ml; | 咨询 |
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| T834999 | MACKLIN | 三氟拉嗪二盐酸盐 | ≥99% | 112元/1g; 335元/5g; 868元/25g; | 咨询 |
储存：2~8°C,密封 状态：白色-非常淡黄色晶体-粉末 |
| T2849 | TCI | Trifluoperazine Dihydrochloride | >98.0%(T)(HPLC) | 590元/5G; 1490元/25G; | 咨询 |
基本信息 | 纯度/分析方法 | >98.0%(T)(HPLC) | | 分子式/分子量 | C21H24F3N3S・2HCl = 480.42 | | 外观与形状(20℃) | 固体 | | 储存温度 | <0℃ | | 应避免的情况 | 加热 | | 相关CAS RN | 117-89-5&605-75-4 | | Reaxys-RN | 3820024 | | PubChem物质ID | 160871333 | | Merck Index (14) | 9680 | | MDL编号 | MFCD00012656 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(HPLC) | min. 98.0 area% | | Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) | | Drying loss | max. 3.0 % |
物性(参考值) | 熔点 | 293 ℃(dec.) | | 最大吸收波长 | 312(MeOH) nm | | 水溶性 | 完全溶解 | | 溶解性(不溶于) | 苯,乙醚 |
安全信息 | 图形或危害标志 |   | | 信号词 | 警告 | | 危险性说明 | H302 : 吞咽有害。
H361 : 怀疑对生育能力或胎儿造成伤害。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。
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相关法规 |
| 326356 | J&K | Trifluoperazine Dihydrochloride | 99%, 一种细胞渗透钙调素拮抗剂 | 627元/5G; 1891元/25G; | 咨询 |
基本信息 | 分子式 | C21H24F3N3S·2HCl | | 分子量 | 480.42 | | 熔点 | 243 | | MDL编码 | MFCD00012656 | | Beilstein | 3820024 | | Merck | 14,9680 | | EINECS 编号 | 207-123-0 | | 存储条件 | Freezer -20℃ |
产品描述 Trifluoperazine 2HCl是一种多巴胺D2受体抑制剂，IC50为1.1 nM。 靶点（IC50 & Targe） Dopamine D2 receptor [1],1.1 nM 体外研究 Trifluoperazine结合到α1A-和α1B-肾上腺受体，Ki值分别为27.6 nM 和19.2 nM，α1B/α1A比率为0.7。[2] Trifluoperazine抑制结核分枝杆菌(Mtb)，MICs为7.6 μg/mL。[3] Trifluoperazine (< 14.78 mM)剂量依赖性抑制小鼠脾脏NK细胞毒活性和效应器-靶点细胞接合。Trifluoperazine抑制干扰素-α或者白细胞介素-2诱导的NK细胞毒活性的增加。[4] Trifluoperazine抑制电压依赖性钾通道Kv2.1来自人大脑中(hKv2.1)的基因表达。[5] 体内研究 间断性试验回避下行为维持的大鼠中，Trifluoperazine剂量依赖性减少回避反应，并增加响应失误。[6] 参考文献 [1] Lahti RA, et al. Eur J Pharmacol, 1993, 236(3), 483-486. [2] Cahir M, et al. Eur Neuropsychopharmacol, 2005, 15(2), 231-234. [3] Madrid PB, et al. Bioorg Med Chem Lett, 2007, 17(11), 3014-3017. [4] Won SJ, et al. Experientia, 1995, 51(4), 343-348. [5] Motohashi N, et al. Curr Drug Targets, 2000, 1(3), 237-245. [6] Shannon HE, et al. J Pharmacol Exp Ther, 1999, 290(2), 901- 安全信息 | 图形或危害标志 | | | 提示语 | Warning | | 危险说明 | H302 | | 防范说明 | P264
P270
P301+P312
P330
P501 | | WGK | 3 | | RTECS | SP1750000 |
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| T2000000 | | Trifluoperazine hydrochloride | European Pharmacopoeia (EP) Reference Standard | 1259.15元/ ; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 30 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C21H24F3N3S · 2HCl | | 分子量 | 480.42 | | Beilstein | 3820024 | | MDL编号 | MFCD00012656 | | PubChem化学物质编号 | 329826700 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | mp | 243 ℃ (dec.) (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 | | InChI | 1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H | | InChI key | BXDAOUXDMHXPDI-UHFFFAOYSA-N | | Gene Information | human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358) |
安全信息 | 象形图 |  | | 警示用语： | Danger | | 危险声明 | H302 - H319 - H336 - H341 - H372 - H410 | | 预防措施声明 | P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3 | | 靶器官 | Central nervous system, Eyes | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| T8516 | Sigma-Aldrich | Trifluoperazine Dihydrochloride | ≥99%, powder | 1161.11元/5 G; 1723.26元/10 G; | 咨询 |
产品说明 应用 三氟哌嗪二盐酸盐已被用于：
- 抑制网格蛋白依赖型内吞
- 作为培养的加州海兔神经元中的钙调蛋白激酶拮抗剂
- 作为小鼠十二指肠质组织质膜Ca2+-ATP酶 (PMCA) 抑制剂阻断跨细胞活性钙通道
三氟哌嗪二盐酸盐在培养的 海兔神经元中已被用作钙调蛋白 激酶拮抗剂。三氟哌嗪二盐酸盐也已被用作小鼠十二指肠组织中的一种PMCA抑制剂，以阻断跨细胞活性钙流动。 包装 5, 10 g in glass bottle 生化/生理作用 三氟拉嗪二盐酸盐可用于治疗精神分裂、行为失常、严重焦虑、呕心和呕吐。
吩噻嗪类抗精神病药；D2多巴胺受体拮抗剂；抑制3′:5′-环核苷酸磷酸二酯酶的钙调蛋白依赖性刺激；抑制cAMP门控阳离子通道。 特点和优势 该化合物出现在受体分类和信号转导手册的钾离子通道页。欲浏览其他手册页，点击此处。 制备说明 在按需加热时，三氟拉嗪二盐酸盐可以50 mg/ml溶于水，产生澄清的无色至黄色溶液。它也可溶于DMSO和乙醇(5 mg/ml)。 基本信息 | 经验(实验)分子式 | C21H24F3N3S · 2HCl | | 分子量 | 480.42 | | Beilstein | 3820024 | | EC 号 | 207-123-0 | | MDL编号 | MFCD00012656 | | PubChem化学物质编号 | 57654709 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥99% | | 形式 | powder | | 颜色 | white to off-white | | mp | 243 ℃ (dec.) (lit.) | | 溶解性 | ethanol: soluble 5 mg/mL
H2O: soluble 50 mg/mL, clear, colorless to yellow
DMSO: soluble | | 储存温度 | −20℃ | | SMILES string | Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 | | InChI | 1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H | | InChI key | BXDAOUXDMHXPDI-UHFFFAOYSA-N | | Gene Information | human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H302 - H319 - H336 - H341 - H372 - H410 | | 预防措施声明 | P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3 | | 靶器官 | Central nervous system, Eyes | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| T6062 | Sigma-Aldrich | Trifluoperazine hydrochloride | meets USP testing specifications | 1438.84元/5 G; | 咨询 |
基本信息 | 经验(实验)分子式 | C21H24F3N3S · 2HCl | | 分子量 | 480.42 | | Beilstein | 3820024 | | EC 号 | 207-123-0 | | MDL编号 | MFCD00012656 | | PubChem化学物质编号 | 24900344 |
产品性质 | 质量水平 | 200 | | agency | USP/NF
meets USP testing specifications | | 测定 | 98-101% dry basis | | 形式 | powder | | mp | 243 ℃ (dec.) (lit.) | | 溶解性 | water: 50 g/L, clear | | application(s) | pharmaceutical (small molecule) | | 储存温度 | −20℃ | | SMILES string | Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 | | InChI | 1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H | | InChI key | BXDAOUXDMHXPDI-UHFFFAOYSA-N | | Gene Information | human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H302 - H319 - H336 - H341 - H372 - H410 | | 预防措施声明 | P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3 | | 靶器官 | Central nervous system, Eyes | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| 1685000 | USP | Trifluoperazine hydrochloride | United States Pharmacopeia (USP) Reference Standard | 3231.47元/200 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C21H24F3N3S · 2HCl | | 分子量 | 480.42 | | Beilstein | 3820024 | | MDL编号 | MFCD00012656 | | PubChem化学物质编号 | 329751398 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | mp | 243 ℃ (dec.) (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 | | InChI | 1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H | | InChI key | BXDAOUXDMHXPDI-UHFFFAOYSA-N | | Gene Information | human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H302 - H319 - H336 - H341 - H372 - H410 | | 预防措施声明 | P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3 | | 靶器官 | Central nervous system, Eyes | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 358126 | Fluorochem | 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride | >98.0%(HPLC)(T) | 1650元/5g; 4070元/25g; | 咨询 |
基本信息 | CAS Number | 440-17-5 | | MDL Number | MFCD00012656 |
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