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CAS: 4271-30-1
分子式: C12H14N2O5
分子量: 266.25
熔点: ~175 °C (dec.)
中文名称: 
N-对氨基苯甲酰-L-谷氨酸
对氨基苯甲酰基麸质酸
英文名称: 
4-aminobenzoylglutamic acid
n-(4-aminobenzoyl)-l-glutamic acid
N-(P-Aminobenzoyl)-L-glutamic acid
N-(P-Aminobenzoyl)-L-(+)glutamicacid
性质描述: 无色结晶。熔点173℃。能溶于水,微溶于醇,不溶于醚。
生产方法: 对硝基苯甲酰氯与谷氨酸缩合,再用硫化铵还原而得:工艺过程如下:(1)缩合 将水、氧化镁、谷氨酸投入反应罐,调pH至8-9,搅拌使物料全部溶解。降温至20℃,缓缓滴加对硝基苯甲酰氯的苯溶液,控制温度不超过30℃,pH不低于7.5,反应液由白色变紫红色到褪色。加完后继续搅拌1-2h。静置分层,取下层水溶液过滤,上层苯液用少量水冼,水洗液与滤液合并,用盐酸调整PH至3-3.5,静置,析出对硝基苯甲酸,过滤,滤液加盐酸调至pH=1,强力搅拌,然后静置24h,析出结晶。过滤,得N-对硝基苯甲酰谷氨酸,熔点110-112℃。收率73%。(2)还原 将水、N-对硝基苯甲酰谷氨酸混合后,加入硫化铵,搅拌使溶解,缓缓加热煮沸蒸发至溶液pH6-7、体积的1/3时,停止加热,加活性炭脱色,过滤。滤液自然冷却到室温,用盐酸调至pH3-3.5,静置24h,析出结晶,过滤,滤饼用水洗涤,干燥,得N-对氨基苯甲酰-L-谷氨酸,熔点170-172℃,收率58%。
用途: 医药中间体,用于甲氨喋呤、叶酸的生产。
推荐供应商
货号品牌产品名称规格包装、参考价格
N800913MACKLINN-(4-氨基甲酰)-L-谷氨酸97%28元/1g;   30元/5g;   33元/25g;   95元/100g;   468元/500g;   2200元/2.5kg;   咨询
储存:2-8°C
状态:白色至淡黄色结晶粉末
A0442TCIN-(4-Aminobenzoyl)-L-glutamic Acid>97.0%(T)795元/1G;   2650元/5G;   咨询

基本信息

纯度/分析方法>97.0%(T)
分子式/分子量C12H14N2O5 = 266.25
外观与形状(20℃)固体
Reaxys-RN2816320
PubChem物质ID87562068
SDBS (AIST Spectral DB)10503
Merck Index (14)426
MDL编号MFCD00042821

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(Neutralization titration)min. 97.0 %
Specific rotation [a]20/D-13.0 to -17.0 deg(C=2, 0.1mol/L HCl)
Solubility in hot Watervery faint turbidity

物性(参考值)

熔点170 ℃(dec.)
比旋光度 [α]D-15° (C=2,0.1mol/l HCl)
Y10895Alfa Aesar(4-Aminobenzoyl)-L-glutamic acid109元/1g;   咨询

基本信息

分子量
266.25

Y0001242Folic acid impurity AEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C12H14N2O5
分子量266.25
Beilstein2816320
MDL编号MFCD00042821
PubChem化学物质编号329831319
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringNc1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/t9-/m0/s1
InChI keyGADGMZDHLQLZRI-VIFPVBQESA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
A0879Sigma-AldrichN-(4-Aminobenzoyl)-L-glutamic acid≥98% (TLC)3581.69元/5 G;   咨询

产品说明

应用

N-(4-氨基苯甲酰基)-L-谷氨酸(ABG)可用作一种强紫外吸收标签,用于寡糖的衍生化,衍生化的寡糖更容易在毛细管区带电泳等分析方法中检测到。

生化/生理作用

N-对氨基苯甲酰基)-L-谷氨酸是一种叶酸分解代谢物,其可被具有对氨基苯甲酰基-谷氨酸水解酶的细菌对氨基苯甲酸营养缺陷型代谢。

基本信息

经验(实验)分子式C12H14N2O5
分子量266.25
Beilstein2816320
EC 号224-261-7
MDL编号MFCD00042821
PubChem化学物质编号24890463
NACRESNA.26

产品性质

质量水平200
测定≥98% (TLC)
形式powder
颜色 off-white to yellow
mp175 ℃ (dec.)
application(s)detection
peptide synthesis
储存温度−20℃
SMILES stringNc1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/t9-/m0/s1
InChI keyGADGMZDHLQLZRI-VIFPVBQESA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
PHR1334SupelcoFolic acid impurity APharmaceutical Secondary Standard; Certified Reference Material1653.45元/500 MG;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3324 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C12H14N2O5
分子量266.25
Beilstein2816320
EC 号224-261-7
MDL编号MFCD00042821
PubChem化学物质编号329823319
NACRESNA.24

产品性质

质量水平300
100
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur Y0001242
traceable to USP 1019870
储存温度2-30℃
SMILES stringNc1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/t9-/m0/s1
InChI keyGADGMZDHLQLZRI-VIFPVBQESA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1019870USP4-Aminobenzoylglutamic acidUnited States Pharmacopeia (USP) Reference Standard3231.47元/50 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C12H14N2O5
分子量266.25
Beilstein2816320
MDL编号MFCD00042821
PubChem化学物质编号329748979
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringNc1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/t9-/m0/s1
InChI keyGADGMZDHLQLZRI-VIFPVBQESA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
079283Fluorochem(S)-2-(4-Aminobenzamido)pentanedioic acid95%220元/1g;   220元/5g;   330元/10g;   572元/25g;   1650元/100g;   咨询

基本信息

CAS Number4271-30-1
MDL NumberMFCD00042821
Melting Point174-176℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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