CAS 42521-82-4; 1,1′-disulfanediyldinaphthalen-2-ol; ipa-3

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货号

品牌

产品名称

规格

包装、参考价格

I794230

MACKLIN

IPA-3

10mM in DMSO

648元/1ml;

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储存：-20°C

I872635

MACKLIN

IPA-3

95%

334元/5mg;

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储存：-20℃
状态：粉末

506106

Sigma-Aldrich

p21-Activated Kinase Inhibitor III, IPA-3-CAS 42521-82-4-Calbiochem

The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosp

1763.65元/5 MG; 6303元/25 MG;

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产品说明

一般描述

A cell-permeable symmetrical disulfide allosteric inhibitor that selectively targets the autoregulatory domain of group I, but not group II, PAKs (p21-activated kinases) and prevents the activation of PAK1/2/3 (% inhibition= 95, 70, and 60, respectively, with 10 µM inhibitor; IC₅₀ = 2.5 µM for PAK1). Specificity test shows ≥ 50% inhibition, in the presence of 10 µM ATP and inhibitor, against 9 of 214 non-PAK human kinases. Shown to effectively suppress both basal and PDGF-induced PAK activation at 30 µM in mouse embryonic fibroblasts. IPA-3 does not inhibit the enzymatic activity of preactivated PAKs and reduction of the intramolecular disulfide bond of IPA-3 by DTT renders it inactive.

包装

5, 25 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Irritant (B)

其他说明

Deacon, S.W., et al. 2008. Chem. Biol.15, 322.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₀H₁₄O₂S₂
分子量	350.45
MDL编号	MFCD00388917

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 10 mg/mL ethanol: 2 mg/mL
运输	wet ice
储存温度	−20℃

安全信息

象形图
警示用语：	Danger
危险声明	H318 - H410
预防措施声明	P273 - P280 - P305 + P351 + P338 - P391 - P501
危险分类	Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

I2285

Sigma-Aldrich

IPA-3

≥95% (HPLC), powder

1458.92元/5 MG; 4487.41元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

IPA-3是Pak1的变构抑制剂。它与pak1(p21激活激酶)的自身抑制结构域结合，在激酶中具有高选择性。 Pak1与肿瘤发生和转移有关。

基本信息

经验(实验)分子式	C₂₀H₁₄O₂S₂
分子量	350.45
MDL编号	MFCD00388917
PubChem化学物质编号	329815364
NACRES	NA.77

产品性质

质量水平	200
测定	≥95% (HPLC)
形式	powder
颜色	off-white to yellow
溶解性	DMSO: >20 mg/mL H₂O: insoluble
储存温度	2-8℃
SMILES string	Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34
InChI	1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChI key	RFAXLXKIAKIUDT-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H318 - H410
预防措施声明	P273 - P280 - P305 + P351 + P338 - P501
危险分类	Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

511627

Fluorochem

1,1'-Disulfanediylbis(naphthalen-2-ol)

95+%

13772元/250mg; 24926元/500mg; 45188元/1g;

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基本信息

CAS Number	42521-82-4
MDL Number	MFCD00388917