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CAS: 42438-90-4
分子式: C12H12N2O2
分子量: 216.24
英文名称: 
(S)-(-)-2,3,4,9-TETRAHYDRO-1H-PYRIDO-(3,4-B)INDOLE-3-CARBOXYLIC ACID
推荐供应商
货号品牌产品名称规格包装、参考价格
S916969MACKLIN(s)-2,3,4,9-四氢-1H-吡啶[3,4-b]吲哚-3-羧酸98% (HPLC)92元/100mg;   139元/250mg;   369元/1g;   680元/5g;   1550元/25g;   咨询
储存:-20°C
状态:白色到灰白色到米黄色到浅黄色到黄色粉末
SML1711Sigma-AldrichTNCA≥98% (HPLC)772.29元/10 MG;   3149.63元/50 MG;   咨询

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

基本信息

经验(实验)分子式C12H12N2O2
分子量216.24
MDL编号MFCD00272641
PubChem化学物质编号329826033
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
颜色 white to beige
溶解性 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
储存温度−20℃
SMILES stringO=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
InChI1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
InChI keyFSNCEEGOMTYXKY-JTQLQIEISA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
330964Fluorochem(S)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID95%572元/1g;   2002元/5g;   7678元/25g;   咨询

基本信息

CAS Number42438-90-4
MDL NumberMFCD01444861

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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