CAS 4238-41-9; 1-chloro-3-tosylamido-7-amino-2-heptanonehydrochloride

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

N723183

MACKLIN

Nalpha-(p-甲苯磺酰基)-DL-赖氨酸氯甲基酮盐酸盐

≥95%

2600元/25mg;

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储存：-20°C

J63959

Alfa Aesar

Nalpha-(p-Toluenesulfonyl)-DL-lysine chloromethyl ketone hydrochloride

98%

2112元/50mg; 3971元/100mg; 5462元/250mg;

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应用
Inhibitor of papain and trypsin

基本信息

MDL
MFCD00012513

EINECS
224-199-0

分子式
C₁₄H₂₁ClN₂O₃S?HCl

分子量
369.31

灵敏度
Store at -20°C.

形态
Powder

溶解性
Soluble in water

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

RTECS
XT5160000

TSCA
否

616382

Sigma-Aldrich

N^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride-CAS 4238-41-9-Calbiochem

Inhibits trypsin-like serine proteinases.

1560.15元/50 MG; 4521.72元/250 MG;

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产品说明

一般描述

Inhibits trypsin-like serine proteases. Inactivates trypsin irreversibly without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC₅₀ = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Suggesting working concentration is 10-100 µM.
Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC₅₀ = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.

包装

50, 250 mg in Plastic ampoule

生化/生理作用

EC50 = 80 µM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
trypsin like proteases

警告

Toxicity: Irritant (B)

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Kim, H., et al. 1995. J. Immunol.154, 4741.
Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230.
Biro, A., et al. 1992. Eur. J. Immunol.22, 2547.
Bruno, S., et al. 1992. Leukemia6, 1113.
Lee, S.F. 1992. Infect. Immun. 60, 4032.
Schmidt, H.H., et al. 1992. Mol. Pharmacol.41, 615.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₄H₂₁ClN₂O₃S · xHCl
分子量	332.85 (free base basis)

产品性质

质量水平	100
测定	≥95% (elemental analysis)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
颜色	off-white
溶解性	aqueous solution, pH <6.0: 1 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
InChI key	YFCUZWYIPBUQBD-ZOWNYOTGSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable