CAS 420831-40-9; AK-7 - �뵺�羺�ٷ��ַ

位置：首页 > 资料中心 > 化工字典 > 420831-40-9

CAS:

420831-40-9

分子式:

C₁₉H₂₁BrN₂O₃S

分子量:

437.35

中文名称:

AK-7

用途:

AK-7 是一种可透过细胞及血脑屏障的 SIRT2 抑制剂，IC50 值为 15.5 μM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

A879079

MACKLIN

AK-7

99%

576元/10mg; 2052元/50mg; 6570元/250mg;

咨询

储存：2-8℃
状态：白色到灰白色固体

SML0152

Sigma-Aldrich

AK-7

≥98% (HPLC)

1098.72元/5 MG; 4441.15元/25 MG;

咨询

产品说明

一般描述

AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.

应用

AK-7 has been used in cell culture and cell treatment.

包装

5, 25 mg in glass bottle

生化/生理作用

In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.
Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
Selective SIRT2 Inhibitor
AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.

基本信息

经验(实验)分子式	C₁₉H₂₁BrN₂O₃S
分子量	437.35
MDL编号	MFCD03140195
PubChem化学物质编号	329825200
NACRES	NA.25

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to tan
溶解性	DMSO: ≥15 mg/mL
储存温度	2-8℃
SMILES string	Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1
InChI	1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
InChI key	IYAYHZZWYNXHEQ-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9