| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| L798235 | MACKLIN | LY-364947 ,HTS 466284 | 2mM in DMSO | 308元/1ml; | 咨询 |
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| L860932 | MACKLIN | LY-364947 ,HTS 466284 | >98% | 179元/5mg; 284元/10mg; 389元/50mg; | 咨询 |
储存：-20℃ 状态：黄色粉末 折射率：light yellow solid |
| L6293 | Sigma-Aldrich | LY-364947 | ≥98% (HPLC) | 2457.91元/5 MG; 7667.92元/25 MG; | 咨询 |
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 LY-364947 是转化生长因子-β I 型受体激酶(TGF-β RI，ALK5)的选择性 ATP 竞争性抑制剂，IC50 = 59 nM。它对相关激酶的效力要差得多，TGF-β RII 的 IC50 = 400 nM ，混合谱系激酶 7(MLK-7)(MAP 激酶信号途径中的激酶，与 TGF-β RII 密切相关)的 IC50 = 1400 nM。LY-364947 抑制 NIH 3T3 小鼠成纤维细胞中 TGF-β 依赖性细胞生长(IC50 = 81 nM)。 基本信息 | 经验(实验)分子式 | C17H12N4 | | 分子量 | 272.30 | | MDL编号 | MFCD00800758 | | PubChem化学物质编号 | 24724526 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | powder | | 颜色 | white to beige | | 溶解性 | DMSO: 2 mg/mL, clear | | 储存温度 | 2-8℃ | | SMILES string | c1ccc(nc1)-c2n[nH]cc2-c3ccnc4ccccc34 | | InChI | 1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) | | InChI key | IBCXZJCWDGCXQT-UHFFFAOYSA-N | | Gene Information | human ... TGFBR1(7046) |
安全信息 | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
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| 023739 | Fluorochem | 4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline | 97% | 880元/250mg; 2002元/1g; 6776元/5g; | 咨询 |
基本信息 | CAS Number | 396129-53-6 | | MDL Number | MFCD00800758 | | Melting Point | > 230℃ (dec.) |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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