产品说明

一般描述

A cell-permeable inhibitor of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
A cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
TNF-α-stimulated NF-κB activation and upregulation of MMP-9
Product does not compete with ATP.
Reversible: no
Effective concentration: 10 µM for complete inhibition of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells

警告

Toxicity: Irritant (B)

其他说明

Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun.336, 716.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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