CAS 37762-06-4; 2-(2-丙氧苯基)-6-羟基-8-氮杂嘌呤; 2-(2-Propoxyphenyl)-6-hydroxy-8-azapurine

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CAS:

37762-06-4

分子式:

C13H13N5O2

分子量:

271.28

熔点:

237-238°C dec.

中文名称:

2-(2-丙氧苯基)-6-羟基-8-氮杂嘌呤

2-(2-丙氧苯基)-8-氮杂次黄嘌呤

英文名称:

2-(2-Propoxyphenyl)-6-hydroxy-8-azapurine

2-(2-Propoxyphenyl)-8-azahypoxanthine

zaprinast

性质描述:

棱状结晶（甲醇）。熔点241℃（分解）。

用途:

敏喘宁的中间体。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

Z920140

MACKLIN

2-(2-丙氧苯基)-8-氮杂次黄嘌呤

98%

2965元/100mg;

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储存：2-8℃

Z0878

Sigma-Aldrich

Zaprinast

solid

1208.06元/25 MG; 3936.36元/100 MG;

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产品说明

应用

扎普司特已被用于通过生发泡破裂(GVBD)检测测定其对卵母细胞减数分裂的影响，并用于通过免疫组织化学测试其对视网膜细胞的抑制作用。

包装

25, 100 mg in poly bottle

生化/生理作用

扎普司特对磷酸二酯酶10和11(PDE10和PDE11)没有实质性的抑制作用。它还具有血管舒张作用。
cGMP 特异性磷酸二酯酶 V 和 VI (PDE5/6) 选择性抑制剂和 G 蛋白偶联受体 35 (GPR35) 激动剂。

基本信息

经验(实验)分子式	C₁₃H₁₃N₅O₂
分子量	271.27
EC 号	253-655-1
MDL编号	MFCD00214073
PubChem化学物质编号	24278072

产品性质

质量水平	200
形式	solid
颜色	white
溶解性	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL DMSO: 10 mg/mL H₂O: insoluble
SMILES string	CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
InChI	1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
InChI key	REZGGXNDEMKIQB-UHFFFAOYSA-N
Gene Information	human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

M02689

Fluorochem

Zaprinast

>99%

3894元/50mg; 7084元/100mg;

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基本信息

CAS Number	37762-06-4
MDL Number	MFCD00214073
Melting Point	235-237℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .

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