CAS 37558-16-0; butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymet

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货号

品牌

产品名称

规格

包装、参考价格

P911315

MACKLIN

Phorbol 12,13-dibutyrate

98%

1038元/1mg;

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储存：-20°C，密闭，干燥

524390

Sigma-Aldrich

Phorbol-12,13-dibutyrate-CAS 37558-16-0-Calbiochem

Strong irritant for mouse skin, but only moderately active as a tumor promoter.

1296.97元/1 MG; 3736.22元/5 MG;

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产品说明

一般描述

Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C (PKC). Stimulates the phosphorylation of Na⁺-K⁺ ATPase, thereby inhibiting its activity. Promotes the expression of iNOS in cultured hepatocytes. PDBu can be diluted to 30 µM in aqueous solutions, so it is commonly used in binding studies or in applications requiring high concentrations. It is easier to remove PDBu than PMA from cells in culture.
Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na⁺,K⁺- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.

包装

1, 5 mg in Alu drum
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
Na⁺,K⁺- ATPase
Reversible: no
Cell permeable: no

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

制备说明

Further dilute with aqueous buffers just prior to use.

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Fisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
Lee, E.J., et al. 1994. Brain Res. 665, 127.
Critz, S.D., et al. 1993. J. Neurochem.60, 1175.
Iredale, P.A., et al. 1993. Biochem. Pharmacol.45, 611.
Critz, S.D., and Byrne J.H. 1992. J. Neurophys.68, 1079.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol.24, 937.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₈H₄₀O₈
分子量	504.61
MDL编号	MFCD00036783

产品性质

质量水平	100
测定	≥99% (HPLC)
形式	solid (crystalline)
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	clear
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
InChI key	BQJRUJTZSGYBEZ-YVQNUNKESA-N

安全信息

象形图
警示用语：	Danger
危险声明	H300 + H310 + H330 - H314 - H317 - H334 - H351
预防措施声明	P201 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类	Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

P1269

Sigma-Aldrich

Phorbol 12,13-dibutyrate

≥98% (TLC), powder

1255.34元/1 MG; 3557.45元/5 MG; 5990.92元/10 MG;

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产品说明

应用

佛波醇12,13-二丁酸酯(二丁酸佛波醇酯)已用作蛋白激酶C(PKC)激活剂，用于研究其对人有机阴离子转运蛋白4(hOAT4)活性的影响。作为PKC激活剂，它也已用于分析其对HL-1细胞中半乳凝素-3表达和基质产生的影响。

包装

1 mg in ampule

生化/生理作用

佛波醇12,13-二丁酸酯(PDBu)是蛋白激酶C(PKC)的强效激活剂。它的亲水性高于佛波醇12-肉豆蔻酸酯13-乙酸酯(PMA)，方便在组织培养中将PDBu洗出细胞。PDBu可激活原代人脐静脉内皮细胞的内皮型一氧化氮合酶表达，进而影响PKCα和ε表达。

特点和优势

疏水性低于 PMA，更容易在组织培养中洗掉细胞。

注意

光敏

重悬

贮备液不能在水性介质中制备；在水介质中稀释至工作浓度前，溶于可溶于水的有机溶剂中。

基本信息

经验(实验)分子式	C₂₈H₄₀O₈
分子量	504.61
Beilstein	6551234
MDL编号	MFCD00036783
PubChem化学物质编号	24898178
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (TLC)
形式	powder
颜色	clear light yellow, film
溶解性	H₂O: 30 μM DMSO: soluble acetone: soluble ethanol: soluble
储存温度	−20℃
SMILES string	CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)[C@H]2C=C(C)C3=O)[C@@H]4C(C)(C)[C@]14OC(=O)CCC
InChI	1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
InChI key	BQJRUJTZSGYBEZ-YVQNUNKESA-N
Gene Information	mouse ... Prkcd(18753)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves