产品说明

包装

50, 250 mg in glass bottle

生化/生理作用

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist with a Kd value of 8.34 μM for PPARγ and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARγ by the PPARγ agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARα agonist, interacting with the PPARα ligand binding domain with a KD of 120 μM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARα.

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产品说明

一般描述

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D = ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.
A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D ~8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

包装

50 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
PPARγ
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
kd = ~ 8 µM as PPARγ antagonist

警告

Toxicity: Standard Handling (A)

制备说明

Addition of a small amount of acid or base may be required for complete solubilization.

重悬

Following reconstitution aliquot freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ye, F., et al. 2006. Chembiochem7, 74.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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