CAS 35922-06-6; (1R, 2R)-n-myristoylamino-4′-nitro-phenylpropandiol-1, 3; d-nmappd

CAS:

35922-06-6

中文名称:

(1R, 2R)-n-myristoylamino-4′-nitro-phenylpropandiol-1, 3

英文名称:

d-nmappd

[r-(r*,r*)]-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide

(1R,2R)-b13

b13

n-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]tetradecanamide

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货号

品牌

产品名称

规格

包装、参考价格

SML2358

Sigma-Aldrich

D-NMAPPD

≥98% (HPLC)

660.71元/5 MG; 2669.38元/25 MG;

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产品说明

生化/生理作用

D-NMAPPD (B13), a myristoyl-CoA analog, is a cell penetrant inhibitor of N-myristoyltransferases that suppressed FRS2α (fibroblast growth factor receptor substrate 2) myristoylation. D-NMAPPD inhibits wild-type FGFRs and drug-resistant mutants (FGFRsDRM) oncogenic signaling in cancer cells. D-NMAPPD potently inhibits growth of xenograft tumors in mice. D-NMAPPD is a potent inhibitor of ceramidase that elevates endogenous ceramide levels and suppress growth of cancer cells.

基本信息

经验(实验)分子式	C₂₃H₃₈N₂O₅
分子量	422.56
MDL编号	MFCD08062172

产品性质

测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -28 to -34, c = 0.1 in chloroform-d
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable