CAS 35920-39-9; 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethyl-ribofuranuronamid hemihydrate

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货号

品牌

产品名称

规格

包装、参考价格

N911309

MACKLIN

5'-N-Ethylcarboxamidoadenosine (NECA)

98%

499元/5mg; 1385元/25mg;

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储存：-20°C，密闭，干燥

N793107

MACKLIN

5'-N-Ethylcarboxamidoadenosine (NECA)

10mM in DMSO

410元/1ml;

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储存：-20°C

528753

J&K

5'-Ethylcarboxamidoadenosine

98%

1596元/25MG; 4522元/100MG;

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基本信息

分子式	C₁₂H₁₆N₆O₄
分子量	308.29
MDL编码	MFCD00069195
存储条件	Store at 2-8℃

安全信息

图形或危害标志
提示语	Danger
危险说明	H300
防范说明	P264 P301+P310
UN号码	2811
危险分类	6.1
包装等级	II
WGK	3
RTECS	VJ2232000

E2387

Sigma-Aldrich

5′-(N-Ethylcarboxamido)adenosine

powder

2684.1元/50 MG;

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产品说明

一般描述

5′-(N-乙基酰胺基)腺苷通过 A₂-腺苷受体激活刺激肺循环中的血管舒张。

应用

5′-(N-乙基酰胺基)腺苷用于：

纯化癸基麦芽糖苷(DM)中的人腺苷A_2A受体(A_2AR)
确定腺苷受体非特异性结合情况
通过竞争性测定研究腺苷2B受体(RA2B)的作用机理

包装

50 mg in poly bottle

生化/生理作用

强效腺苷受体激动剂与 A ₁ 和 A ₂ 受体的亲和力几乎相等。

特点和优势

该化合物已被列于《受体分类和信号转导手册》的腺苷受体页面中。若要浏览手册其他页面，请单击此处。

基本信息

经验(实验)分子式	C₁₂H₁₆N₆O₄
分子量	308.29
MDL编号	MFCD00069195
PubChem化学物质编号	24277684

产品性质

质量水平	200
形式	powder
颜色	white
溶解性	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 ℃.) DMSO: 14 mg/mL (Solutions may be stored for several days at 4 ℃.) 0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 ℃.) H₂O: insoluble ethanol: soluble (Solutions may be stored for several days at 4 ℃.)
储存温度	2-8℃
SMILES string	CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI	1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
InChI key	JADDQZYHOWSFJD-FLNNQWSLSA-N
Gene Information	human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P301 + P310
危险分类	Acute Tox. 2 Oral
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

119140

Sigma-Aldrich

Adenosine Receptor Agonist, NECA-CAS 35920-39-9-Calbiochem

837.5元/10 MG;

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产品说明

一般描述

A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K_i = 14 nM, 20 nM, 2.4 µM and 6.2 nM for A₁, A_2A, A_2B, A₃, respectively). Increases intracellular cAMP production (EC₅₀ = 3.1 µM in A_2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.

包装

10 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Forster, K., et al. 2006. Basic Res. Cardiol.101, 319.
de Zwart, M., et al. 1998. Nucleosides Nucleotides.17, 969.
Phillis, J. et al. 1986, Pharm. Biochem. Behavior.24, 263
Durcan, M. J., et al. 1989. Pharmacol Biochem Behav.32, 487.
Bacher, S., et al. 1982. Naunyn Schmiedebergs Arch Pharmacol.329, 67.
Cusack, N., et al. 1981. Br J Pharm.72, 443.
Londos, C., et al. 1980. Proc Natl Acad Sci.77, 2551.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₂H₁₆N₆O₄
分子量	308.29
MDL编号	MFCD00069195

产品性质

质量水平	100
测定	≥99% (HPLC)
形式	solid
效能	14 nM K_i
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 50 mM
运输	wet ice
储存温度	2-8℃
InChI	1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12?/m0/s1
InChI key	JADDQZYHOWSFJD-QQIVLSGASA-N

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 2 Oral
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable