| CAS: | 357263-13-9 | |
| 分子式: | C22H22N4O4 | |
| 分子量: | 406.43 | |
| 英文名称: |
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| 用途: | BMS-378806 选择性抑制HIV-1 gp120与CD4受体结合，EC50为0.85-26.5 nM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||
| B873817 | MACKLIN | BMS-378806 | 99% | 535元/1mg; | 咨询 | ||||||||||||||||||||||||||
储存：-20℃ 状态：粉末 | |||||||||||||||||||||||||||||||
| B795123 | MACKLIN | BMS-378806 | 10mM in DMSO | 998元/1ml; | 咨询 | ||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||
| SML3116 | Sigma-Aldrich | BMS-378806 | ≥98% (HPLC) | 911.36元/; 3677.82元/; | 咨询 | ||||||||||||||||||||||||||
产品说明 生化/生理作用 BMS-378806 (BMS-806) is a potent and selective HIV-1 attachment inhibitor that blocks HIV glycoprotein 120 (gp120) from interacting with host T-cell surface glycoprotein CD4 (IC50 = 100 nM against CD4 for binding gp120; CYP1A2/2C9/2C19/2D6/3A4 IC50 >23 μM) without affecting HIV integrase, protease, or reverse transcriptase activity. BMS-806 effectively prevents various HIV-1 isolates from replication (EC50 from 0.85 to 26.5 nM in MT-2 and PM1 cultures; host cytotoxicity IC50 >300 μM) without affecting HIV-2, SIV, MuLV, RSV, HCMV, BVDV, VSV, or influenza virus. 基本信息
产品性质
安全信息
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