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CAS: 356559-13-2
分子式: C20H22ClN3O2
分子量: 371.86
英文名称: 
sb-505124 hydrochloride
用途: SB-505124 hydrochloride 是一种选择性的 TGF-β Receptor type I receptor (ALK4,ALK5,ALK7) 抑制剂,对 LK4,ALK5 的 IC50 值分别为 129 nM 和 47 nM,对 ALK1,2,3 或 6 无作用。
推荐供应商
货号品牌产品名称规格包装、参考价格
S879391MACKLINSB-505124 hydrochloride 98%1148元/10mg;   4018元/50mg;   咨询
储存:2-8℃
616453Sigma-AldrichTGF-β RI Kinase Inhibitor III-CAS 356559-13-2-CalbiochemThe TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphoryla2741.8元/2 MG;   咨询

产品说明

一般描述

A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.

包装

2 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Primary Target
Activin receptor-like kinase 4, 5, 7
Reversible: yes
Target IC50: 129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol.289, F816.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol.65, 744.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H21N3O2 · xHCl
分子量335.40 (free base basis)

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色light yellow
溶解性DMSO: 20 mg/mL
water: 3 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9
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