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CAS: 348-57-2
分子式: C6H3BrF2
分子量: 193
沸点: 145℃
熔点: -4-146℃
中文名称: 
2,4-二氟溴苯
1-溴-2,4-二氟苯
英文名称: 
1-Bromo-2,4-difluorobenzene
Bromo-2,4-difluorobenzene
2,4-Difluorobromobenzene
性质描述: 无色透明液体。熔点-4℃,沸点145-146℃,闪点51℃,相对密度1.708,折射率1.5050。可与苯混溶。
生产方法: 由间二氟苯溴化而得。将间二氟苯与四氯化碳及铁粉混合,搅拌加热至45℃左右,慢慢滴加由溴与四氯化碳组成的溶液,滴完后继续搅拌30min,至无色烟产生为止。冷却,加入20%亚硫酸氢钠溶液,搅拌至无色。分出有机层,用10%氢氧化钠液洗涤,水洗至中性。用无水硫酸钠干燥过夜。进行常压蒸馏,收集144-148℃馏分,得到本品,收率83%.
用途: 用于合成广谱低毒深部抗真菌药物氟康唑(fluconazole)等的中间体。
推荐供应商
货号品牌产品名称规格包装、参考价格
B742803MACKLIN2,4-二氟溴苯Standard for GC, ≥99.7%(GC)128元/5g;   咨询
储存:2-8°C
状态:液体
B801947MACKLIN2,4-二氟溴苯98%32元/25g;   117元/100g;   568元/500g;   2100元/2.5kg;   咨询
储存:2~8°C
状态:无色到黄色液体
折射率:n20/D 1.505(lit.)
D1909TCI1-Bromo-2,4-difluorobenzene>98.0%(GC)190元/25G;   550元/100G;   1890元/500G;   咨询

基本信息

纯度/分析方法>98.0%(GC)
分子式/分子量C6H3BrF2 = 192.99
外观与形状(20℃)液体
Reaxys-RN1680892
PubChem物质ID87568369
SDBS (AIST Spectral DB)15134
MDL编号MFCD00000330

技术规格

AppearanceColorless to Light yellow clear liquid
Purity(GC)min. 98.0 %

物性(参考值)

沸点146 ℃
闪点51 ℃
比重1.71
折射率1.51

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H226 : 易燃液体和蒸气。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P240 : 容器和装载设备接地/等势联接。
P210 : 远离热源/火花/明火/热表面。禁止吸烟。
P233 : 保持容器密闭。
P243 : 采取防止静电放电的措施。
P241 : 使用防爆的电气/通风/照明设备。
P242 : 只能使用不产生火花的工具。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P370 + P378 : 火灾时:使用干砂、干粉或抗醇泡沫灭火。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P303 + P361 + P353 : 如皮肤(或头发)沾染:立即脱掉所有沾污的衣物。用水清洗皮肤/淋浴。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P403 + P235 : 存放在通风良好的地方。保持低温。

运输信息

UN编号UN1993
类别3
包装类别 III
监管条件代码(*)
203238J&K1-Bromo-2,4-difluorobenzene98%117元/25G;   355元/100G;   咨询

基本信息

分子式C6H3BrF2
分子量192.99
熔点-4
沸点145-146
闪点52
密度1.708
折光率(n20D)1.5050
MDL编码MFCD00000330
Beilstein1680892
EINECS 编号206-479-4

安全信息

图形或危害标志
提示语Warning
危险说明H226
H315
H319
H335
防范说明P261
P305+P351+P338
UN号码1993
危险分类3
包装等级III
WGK3
TSCA
A14098Alfa Aesar1-Bromo-2,4-difluorobenzene98+%830元/25g;   2564元/100g;   11925元/500g;   咨询

基本信息

MDL
MFCD00000330

EINECS
206-479-4

分子式
C6H3BrF2

分子量
192.99

熔点
-4°

沸点
145-146°

闪点
51°(123°F)

密度
1.708

折射率
1.5050

灵敏度
Ambient temperatures.

形态
Liquid

Beilstein
1680892

GHS危害和防范说明

GHS符号

Hazard Statements
H226-H315-H319-H335
Flammable liquid and vapour.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Avoid breathing dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

UN#
UN1993

危险等级
3

包装组
III

危险类别
10-36/37/38
Flammable.Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

TSCA

C24936Alfa Aesar1-Bromo-2,4-difluorobenzene98+%631元/10ml;   3610元/50ml;   咨询

基本信息

Ref#
24936

MDL
330

分子式
C6 H3 Br F2

分子量
192.99

闪点
51

密度
1708

安全信息

危险等级
3

包装组
III

001462Fluorochem1-Bromo-2,4-difluorobenzene98%594元/100g;   836元/250g;   咨询

基本信息

CAS Number348-57-2
MDL NumberMFCD00000330
Boiling Point145-146℃
Melting Point-4℃
Density1.708

安全信息

图形或危害标志
危险性说明 H226: Flammable liquid and vapour.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P210: Keep away from – No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof ./ equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P370 + P378: In case of fire: Use sand, CO2 or extinguishing powder for extinction.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P403 + P235: Store in a well-ventilated place. Keep cool.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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