产品说明
应用
AH6809 has been used:
- as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia
- as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines
- as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)
包装
5 mg in glass bottle
生化/生理作用
AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.
DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP1 and EP2 prostanoid receptors.
特点和优势
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C17H14O5 |
| 分子量 | 298.29 |
| MDL编号 | MFCD08056083 |
| PubChem化学物质编号 | 329770690 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% |
| 形式 | crystalline solid or supercooled liquid |
| 溶解性 | ethanol: soluble 2.5 mg/mL
DMSO or DMF: soluble 8 mg/mL |
| SMILES string | CC(C)Oc1ccc2c(Oc3ccc(cc3C2=O)C(O)=O)c1 |
| InChI | 1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20) |
| InChI key | AQFFXPQJLZFABJ-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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