| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| D835096 | MACKLIN | (+)-顺-地尔硫卓盐酸盐 | ≥98% | 90元/1g; 298元/5g; 889元/25g; 3550元/100g; | 咨询 |
|
| D794430 | MACKLIN | (+)-顺-地尔硫卓盐酸盐 | 10mM in DMSO | 665元/1ml; | 咨询 |
|
| D3662 | TCI | (+)-cis-Diltiazem Hydrochloride | >98.0%(T)(HPLC) | 890元/5G; 2690元/25G; | 咨询 |
基本信息 | 纯度/分析方法 | >98.0%(T)(HPLC) | | 分子式/分子量 | C22H26N2O4S・HCl = 450.98 | | 外观与形状(20℃) | 固体 | | 储存温度 | 0-10℃ | | 储存在惰性气体下 | 存放于惰性气体之中 | | 应避免的情况 | 光,空气,加热 | | 相关CAS RN | 42399-41-7 | | Reaxys-RN | 4228706 | | PubChem物质ID | 87560433 | | MDL编号 | MFCD00069252 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(HPLC) | min. 98.0 area% | | Purity(Nonaqueous Titration) | min. 98.0 % | | Specific rotation [a]20/D | 114 to 122 deg(C=1, H2O) |
物性(参考值) | 熔点 | 210 ℃ | | 比旋光度 [α]D | 118° (C=1,H2O) | | 水溶性 | 可溶 |
安全信息 | 图形或危害标志 |  | | 信号词 | 警告 | | 危险性说明 | H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
|
相关法规 |
| 363524 | J&K | (+)-cis-Diltiazem Hydrochloride | 99% | 846元/5g; 2556元/25G; | 咨询 |
基本信息 | 分子式 | C22H26N2O4S.HCl | | 分子量 | 451.02 | | 熔点 | 210 | | 比旋光度([α]20D) | 114.0 - 122.0(C=1, H2O) | | MDL编码 | MFCD00069252 | | Beilstein | 4228706 | | Merck | 14,3202 | | EINECS 编号 | 251-443-3 | | 存储条件 | Store at 2-8℃ |
安全信息 | 图形或危害标志 | | | 提示语 | Warning | | 危险说明 | H302
H315
H319 | | 防范说明 | P264
P270
P501 | | WGK | 3 | | RTECS | DL0310000 |
|
| D1980000 | | Diltiazem hydrochloride | European Pharmacopoeia (EP) Reference Standard | 1572.16元/ ; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H26N2O4S · HCl | | 分子量 | 450.98 | | Beilstein | 4228706 | | MDL编号 | MFCD00069252 | | PubChem化学物质编号 | 329798720 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O | | InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 | | InChI key | HDRXZJPWHTXQRI-BHDTVMLSSA-N | | Gene Information | human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 | | 预防措施声明 | P301 + P312 + P330 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| Y0001141 | | Diltiazem for system suitability | European Pharmacopoeia (EP) Reference Standard | 1277.32元/ ; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H26N2O4S · HCl | | 分子量 | 450.98 | | Beilstein | 4228706 | | MDL编号 | MFCD00069252 | | PubChem化学物质编号 | 329830782 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O | | InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 | | InChI key | HDRXZJPWHTXQRI-BHDTVMLSSA-N | | Gene Information | human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 | | 预防措施声明 | P301 + P312 + P330 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| D2521 | Sigma-Aldrich | (+)-cis-Diltiazem hydrochloride | ≥99% (HPLC) | 1304.36元/1 G; 4186.71元/5 G; 6950.86元/10 G; | 咨询 |
产品说明 一般描述 盐酸地尔硫卓可用于治疗心血管疾病，例如心绞痛和高血压。它可充当细胞色素P450 3A(CYP3A)的抑制剂。地尔硫卓可能与斑丘疹、荨麻疹和瘙痒有关。 应用 (+)-顺式-盐酸地尔硫卓已用于: - 研究其对整体分散基质(monolithic dispersion matrix)中扩散和释放的影响(26)
- 研究其在视网膜色素变性(RP)模型中的神经保护作用(27)
- 作为Cav1.2 L型钙通道(LTCC)的拮抗剂(28)
包装 1, 5, 10 g in poly bottle 生化/生理作用 封闭缓慢或L-型Ca2+通道；调节来自中性粒细胞内存储的Ca2+的释放；刺激1,4-二氢吡啶结合至Ca2+通道；冠状动脉舒张剂。 特点和优势 这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物由Valeant开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物在《受体分类和信号转导手册》的钙通道和环核苷酸门控(CNG)和超极化激活的环核苷酸门控(HCN)通道页上有说明。要浏览其他手册页，点击此处。 基本信息 | 经验(实验)分子式 | C22H26N2O4S · HCl | | 分子量 | 450.98 | | Beilstein | 4228706 | | EC 号 | 251-443-3 | | MDL编号 | MFCD00069252 | | PubChem化学物质编号 | 24277849 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 测定 | ≥99% (HPLC) | | 创始人 | Valeant | | 储存温度 | 2-8℃ | | SMILES string | Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O | | InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 | | InChI key | HDRXZJPWHTXQRI-BHDTVMLSSA-N | | Gene Information | human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 | | 预防措施声明 | P264 - P270 - P301 + P312 + P330 - P501 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
|
| 1205003 | USP | Diltiazem hydrochloride | United States Pharmacopeia (USP) Reference Standard | 3231.47元/200 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H26N2O4S · HCl | | 分子量 | 450.98 | | Beilstein | 4228706 | | MDL编号 | MFCD00069252 | | PubChem化学物质编号 | 329749607 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O | | InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 | | InChI key | HDRXZJPWHTXQRI-BHDTVMLSSA-N | | Gene Information | human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 | | 预防措施声明 | P301 + P312 + P330 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| PHR2856 | Supelco | Diltiazem hydrochloride | certified reference material, pharmaceutical secondary standard | 2532.07元/500 MG; | 咨询 |
产品说明 一般描述 Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards 分析说明 These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. 其他说明 This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. 基本信息 | 经验(实验)分子式 | C22H26N2O4S · HCl | | 分子量 | 450.98 | | Beilstein | 4228706 | | MDL编号 | MFCD00069252 |
产品性质 | 等级 | certified reference material
pharmaceutical secondary standard | | 描述 | Pharmaceutical Secondary Standard; Certified Reference Material | | 形式 | solid | | 包装 | pkg of 500 mg | | 药典可追溯性 | traceable to PhEur D1980000
traceable to USP 1205003 | | 储存温度 | 2-30℃ | | SMILES string | Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O | | InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 | | InChI key | HDRXZJPWHTXQRI-BHDTVMLSSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 | | 预防措施声明 | P264 - P270 - P301 + P312 - P501 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| BP726 | | Diltiazem hydrochloride | British Pharmacopoeia (BP) Reference Standard | 2052.88元/100 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H26N2O4S · HCl | | 分子量 | 450.98 | | Beilstein | 4228706 | | MDL编号 | MFCD00069252 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | BP | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O | | InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 | | InChI key | HDRXZJPWHTXQRI-BHDTVMLSSA-N | | Gene Information | human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 | | 预防措施声明 | P264 - P270 - P301 + P312 + P330 - P501 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| BP899 | | Diltiazem impurity standard | British Pharmacopoeia (BP) Reference Standard | 1916.08元/25 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H26N2O4S · HCl | | 分子量 | 450.98 | | Beilstein | 4228706 | | MDL编号 | MFCD00069252 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | BP | | 格式 | mixture | | 储存温度 | 2-8℃ | | SMILES string | Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O | | InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 | | InChI key | HDRXZJPWHTXQRI-BHDTVMLSSA-N | | Gene Information | human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 | | 预防措施声明 | P264 - P270 - P301 + P312 + P330 - P501 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| 309866 | Sigma-Aldrich | Diltiazem, Hydrochloride-CAS 33286-22-5-Calbiochem | Synthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist. | 1030.48元/100 MG; | 咨询 |
产品说明 一般描述 Synthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils.
Synthetic (+)-cis isomer that acts as an L-type Ca2+ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils. 包装 100 mg in Plastic ampoule 生化/生理作用 Product does not compete with ATP.
Reversible: no
Primary Target
L-type Ca2+ channel
Cell permeable: no 警告 Toxicity: Harmful & Carcinogenic / Teratogenic (E) 重悬 Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C. 其他说明 van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem.261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem.261, 8146. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C22H26N2O4S · xHCl | | 分子量 | 414.52 (free base basis) | | MDL编号 | MFCD00069252 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze
desiccated (hygroscopic) | | 颜色 | white | | 溶解性 | water: 50 mg/mL
chloroform: soluble
methanol: soluble | | 运输 | ambient | | 储存温度 | 10-30℃ | | InChI | 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 | | InChI key | HDRXZJPWHTXQRI-BHDTVMLSSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 | | 预防措施声明 | P264 - P270 - P301 + P312 - P501 | | 危险分类 | Acute Tox. 4 Oral | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| M01693 | Fluorochem | Diltiazem.HCl | 99.5% | 418元/250mg; 660元/1g; 1738元/5g; 5258元/25g; | 咨询 |
基本信息 | CAS Number | 33286-22-5 | | MDL Number | MFCD00069252 |
安全信息 | 图形或危害标志 |  | | 危险性说明 | H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H361: Suspected of damaging fertility or the unborn child ..
| | 防范说明 | P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P281: Use personal protective equipment as required.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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