CAS 33237-74-0; 3-propanediamine, n,n-diethyl-n'-2-indanyl-n'-phenyl- monohydrochloride

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CAS:

33237-74-0

分子式:

C₂₂H₃₁ClN₂

分子量:

358.95

英文名称:

3-propanediamine, n,n-diethyl-n'-2-indanyl-n'-phenyl- monohydrochloride

3-propanediamine, n-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl- mo

n-(3-(diethylamino)propyl)-n-phenyl-2-indanamin hydrochloride

aprindine hydrochloride

aspenon

fiboran

ms-5075

n,n-diethyl-n'-2-indanyl-n'-phenyl-1,3-propanediamine hydrochloride

3-propanediamine,n,n-diethyl-n'-2-indanyl-n'-phenyl- monohydrochloride

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

A984181

MACKLIN

Aprindine hydrochloride

98%

6650元/5mg;

咨询

储存：-20°C

A7606

Sigma-Aldrich

Aprindine hydrochloride

≥98% (HPLC), solid

1746.39元/10 MG; 6950.86元/50 MG;

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产品说明

应用

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase.

包装

10, 50 mg in glass bottle

生化/生理作用

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₂₂H₃₀N₂ · HCl
分子量	358.95
EC 号	251-418-7
MDL编号	MFCD01698392
PubChem化学物质编号	329770937
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	solid
溶解性	H₂O: >10 mg/mL
储存温度	2-8℃
SMILES string	Cl.CCN(CC)CCCN(C1Cc2ccccc2C1)c3ccccc3
InChI	1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H
InChI key	KIPFVRHNAAZJOD-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

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