[登录] [免费注册]
试剂仪器网
位置:首页 > 资料中心 > 化工字典 > 33016-12-5
关键词:       仅模糊查询
CAS: 33016-12-5
分子式: C19H18N2O2
分子量: 306.36
沸点: 532.7 °C at 760 mmHg
熔点: 182-185 °C
英文名称: 
tn-16
3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione
nsc 239274
推荐供应商
货号品牌产品名称规格包装、参考价格
T918541MACKLINTN-16>98%(LC&N)576元/25mg;   咨询
储存:2-8℃
T3877TCITN-16>98.0%(HPLC)(N)650元/25MG;   2390元/100MG;   咨询

基本信息

纯度/分析方法>98.0%(HPLC)(N)
分子式/分子量C19H18N2O2 = 306.37
外观与形状(20℃)固体
储存温度0-10℃
储存在惰性气体下存放于惰性气体之中
应避免的情况空气,加热
Reaxys-RN21964867
MDL编号MFCD02684017

技术规格

AppearanceWhite to Light yellow to Light orange powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(with Total Nitrogen)min. 98.0 %
Specific rotation [a]20/D-193.0 to -213.0 deg(C=1, CHCL3)

物性(参考值)

熔点185 ℃
T7580Sigma-AldrichTN-16≥98% (HPLC)1505.41元/5 MG;   6080.7元/25 MG;   咨询

产品说明

应用

TN-16 has been used as a microtubule disrupting agent to study its effect on autophagic process in human and mouse mammary carcinoma cell lines .

包装

5, 25 mg in glass bottle

生化/生理作用

3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor that could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials.
TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.
Inhibitor of microtubule assembly

基本信息

经验(实验)分子式C19H18N2O2
分子量306.36
PubChem化学物质编号329826871
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to tan
溶解性DMSO: ≥17 mg/mL
储存温度2-8℃
SMILES stringC\C(Nc1ccccc1)=C2\C(=O)NC(Cc3ccccc3)C2=O
InChI1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13-
InChI keyKWSXUGYAGMSUTN-LGMDPLHJSA-N

安全信息

象形图GHS07GHS09
警示用语:Warning
危险声明H317 - H400
预防措施声明P273 - P280 - P302 + P352
危险分类Aquatic Acute 1 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9
Baidu
map