| CAS: | 329059-55-4 | |||
| 分子式: | C28H36N2O4S | |||
| 分子量: | 496.66 | |||
| 英文名称: |
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| 用途: | BRD7116竞争性地结合到细菌DNA促旋酶, 作用于LSCe 细胞，EC50值为200 nM, 具有非自治性的抗白血病活性。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||
| B879562 | MACKLIN | BRD7116 | ≥99% | 695元/5mg; 1253元/10mg; | 咨询 | ||||||||
储存：2-8℃ | |||||||||||||
| 2286584 | J&K | BRD7116 | 99%, 竞争性地结合到细菌DNA促旋酶, 作用于LSCe 细胞 | 665元/5MG; 1140元/10MG; | 咨询 | ||||||||
基本信息
产品描述 BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity. IC50 value: 200 nM (EC50, for LSCe cells) Target: DNA gyrase BRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (～50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. [1] BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs. 靶点（IC50 & Targe） DNA gyrase 参考文献 [1]. Hartwell KA, et al. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat Chem Biol. 2013 Dec;9(12):840-848 | |||||||||||||
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