CAS 315705-75-0; n-[2-[(2-methoxyphenyl)amino]-4′-methyl[4,5′-bithiazol]-2′-yl]acetamide; jnj0966

CAS:

315705-75-0

分子式:

C₁₆H₁₆N₄O₂S₂

分子量:

360.45

中文名称:

n-[2-[(2-methoxyphenyl)amino]-4′-methyl[4,5′-bithiazol]-2′-yl]acetamide

英文名称:

jnj0966

用途:

JNJ0966是一种高度选择性化合物，抑制MMP-9 zymogen的激活以及随后具有催化活性的酶的生成。JNJ0966对MMP-1, MMP-2, MMP-3, MMP-9或MMP-14的催化活性没有影响，也不抑制MMP-2酶原的激活。

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货号

品牌

产品名称

规格

包装、参考价格

J797302

MACKLIN

JNJ0966

10mM in DMSO

648元/1ml;

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储存：-20°C

J872371

MACKLIN

JNJ0966

99%

238元/1mg;

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储存：-20℃
状态：粉末

SML2588

Sigma-Aldrich

JNJ0966

≥98% (HPLC)

1057.08元/5 MG; 4267.66元/25 MG;

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产品说明

生化/生理作用

JNJ0966 is a potent and highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation. It appears that JNJ0966 binds to a structural pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106. JNJ0966 reduces disease severity in in a mouse experimental autoimmune encephalomyelitis (EAE) model. JNJ0966 does not inhibit activation of MMP-2 zymogen, and has no effect on MMP-1, MMP-2, MMP-3, MMP-9 or MMP-14 catalytic activity.

基本信息

经验(实验)分子式	C₁₆H₁₆N₄O₂S₂
分子量	360.45
MDL编号	MFCD02045222

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable