| CAS: | 313674-97-4 | ||
| 分子式: | C21H17Cl2NO2 | ||
| 分子量: | 386.27 | ||
| 沸点: | 527.0±50.0 °C(Predicted) | ||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| P983956 | MACKLIN | PD-118057 | 99% | 2111元/25mg; 5128元/5mg; 6097元/100mg; 10365元/250mg; 17618元/1g; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
储存：-20°C, 密封, 干燥 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| P5624 | Sigma-Aldrich | PD-118057 | ≥98% (HPLC), solid | 3056.06元/5 MG; 8928.55元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure 特点和优势 This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. 基本信息
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安全信息
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