CAS 304475-63-6; insolution eif-2α inhibitor, salubrinal-cas 304475-63-6-calbiochem; n-(2,2,2-tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide

位置：首页 > 资料中心 > 化工字典 > 304475-63-6

CAS:

304475-63-6

中文名称:

insolution eif-2α inhibitor, salubrinal-cas 304475-63-6-calbiochem

英文名称:

n-(2,2,2-tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

324897

Sigma-Aldrich

InSolution eIF-2α Inhibitor, Salubrinal-CAS 304475-63-6-Calbiochem

The InSolution eIF-2α Inhibitor, Salubrinal, also referenced under CAS 304475-63-6, controls the biological activity of eIF-2α. This small molecule/inhibitor is primaril

3352.28元/5 MG;

咨询

产品说明

一般描述

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC₅₀ ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC₅₀ ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
eIF-2α

警告

Toxicity: Irritant (B)

外形

A 50 mM (5 mg/208 µL) solution of eIF-2α Inhibitor, Salubrinal (Cat. No. 324895) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

其他说明

Boyce, M., et al. 2005. Science307, 935.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₁H₁₇Cl₃N₄OS
分子量	479.81
MDL编号	MFCD00548612

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
运输	dry ice
储存温度	−70℃
SMILES string	S=C(NC(NC(/C=C/C1=CC=CC=C1)=O)C(Cl)(Cl)Cl)NC2=CC=CC3=C2N=CC=C3

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - (refers to pure substance)
闪点(C)	87 ℃ - (refers to pure substance)

324895

Sigma-Aldrich

eIF-2α Inhibitor, Salubrinal-CAS 304475-63-6-Calbiochem

eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apo

2934.43元/5 MG;

咨询

产品说明

一般描述

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC₅₀ ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380)). Prevents HSV replication both in Vero cells (IC₅₀ ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC₅₀ = ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC₅₀ = ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. Also available as a 50 mM solution in DMSO (Cat. No. 324897).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
elF-2α
Target IC₅₀: 3 µM preventing HSV replication both in Vero cells.
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.