| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| H795369 | MACKLIN | 1-肼苯哒嗪盐酸盐 | 2mM in Water | 445元/1ml; | 咨询 |
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| H835127 | MACKLIN | 1-肼苯哒嗪盐酸盐 | 98% | 55元/1g; 144元/5g; 676元/25g; 1951元/100g; | 咨询 |
储存：室温,密封,干燥 状态：白色到浅黄色粉末或晶体 物化性质：溶于水(40 g/L, 25°C) |
| H0409 | TCI | 1-Hydrazinophthalazine Hydrochloride | >99.0%(T)(HPLC) | 330元/5G; 1010元/25G; | 咨询 |
基本信息 | 纯度/分析方法 | >99.0%(T)(HPLC) | | 分子式/分子量 | C8H8N4・HCl = 196.64 | | 外观与形状(20℃) | 固体 | | 相关CAS RN | 86-54-4 | | Reaxys-RN | 3568329 | | PubChem物质ID | 87570812 | | Merck Index (14) | 4763 | | MDL编号 | MFCD00135998 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(HPLC) | min. 99.0 area% | | Purity( Potassium iodate Method) | min. 99.0 % | | Solubility in Water | almost transparency |
物性(参考值) | 熔点 | 273 ℃(dec.) | | 水溶性 | 可溶 | | 在水中的溶解度 | 44.2 g/l 25 ℃ | | 溶解度(极微溶) | 乙醚,醇 |
安全信息 | 图形或危害标志 |   | | 信号词 | 危险 | | 危险性说明 | H301 : 吞咽会中毒。
H361 : 怀疑对生育能力或胎儿造成伤害。
H362 : 可能对母乳喂养的儿童造成伤害。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P263 : 怀孕/ 哺乳期间避免接触。
P260 : 不要吸入粉尘或烟雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑：求医/就诊。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。
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相关法规 运输信息 | UN编号 | UN2811 | | 类别 | 6.1 | | 包装类别 | III | | 监管条件代码(*) | |
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| 117042 | J&K | Hydralazine Hydrochloride | 99%, 一种直接作用的血管舒张剂 | 74元/1G; 222元/5G; | 咨询 |
基本信息 | 分子式 | C8H8N4·HCl | | 分子量 | 196.64 | | MDL编码 | MFCD00135998 | | Beilstein | 3568329 | | Merck | 14,4763 | | EINECS 编号 | 206-151-0 |
产品描述 Hydralazine HCl 是Hydralazine (Apresoline) 的盐酸盐形式，是直接有效的平滑肌松弛剂，IC50为1.9 mM。 靶点（IC50 & Targe） AO 体外研究 Hydralazine损害RAG-2基因的表达上调，并减少二次免疫球蛋白基因重排。Hydralazine颠覆B淋巴细胞自我容忍并通过破坏受体编辑导致致病性自身反应性的产生。[1] Hydralazine直接清除acrolein，降低细胞内acrolein的活性，从而抑制大分子内收。在acrolein开始处理后30分钟后，Hydralazine抑制交联，但在90分钟后是无效的。[2] Hydralazine（0.1-10 mM）抑制炎性巨噬细胞细胞外和细胞内ROS产生，通过ROS清除机制很可能影响黄嘌呤氧化酶（XO）和烟酰胺腺嘌呤二核苷酸/烟酰胺腺嘌呤二核苷酸磷酸（NADH/ NADPH）氧化酶的超氧自由基(O(2)(*-))-产生。Hydralazine(0.1-10 mM)显著减少NO（*）的生成，并且这种效应导致NOS-2基因表达和蛋白合成。Hydralazine也有效地阻止COX-2的基因表达，和蛋白水平和PGE（2）合成的降低相关联。[3] 在豚鼠脊髓体外，Hydralazine不仅保护acrolein介导的损伤，同时也压缩。Hydralazine可以显著减轻acrolein诱导的超氧化物的产生，谷胱甘肽耗尽，线粒体功能障碍，膜完整性的丧失，并降低复合动作电位传导。[4] 体内研究 在小鼠中，Hydralazine剂量依赖性保护血浆标记酶增加，但不是allyl醇产生的肝谷胱甘肽耗竭。 [5] 参考文献 [1] Mazari L, et al. Proc Natl Acad Sci U S A,?007, 104(15), 6317-6322. [2] Burcham PC, et al. Mol Pharmacol,?006, 69(3), 1056-1065. [3] Leiro JM, et al. Int Immunopharmacol,?004, 4(2), 163-177. [4] Hamann K, et al. J Neurochem,?008, 104(3), 708-718. [5] Kaminskas LM, et al. J Pharmacol Exp Ther,?004, 310(3), 10 安全信息 | 图形或危害标志 |  | | 提示语 | Danger | | 危险说明 | H301
H315
H319
H335 | | 防范说明 | P261
P301+P310
P305+P351+P338 | | UN号码 | 2811 | | 危险分类 | 6.1 | | 包装等级 | III | | WGK | 3 | | RTECS | TH9000000 | | TSCA | 是 |
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| B22995 | Alfa Aesar | 1-Hydrazinophthalazine Hydrochloride | 98% | 1162元/5g; 2463元/25g; | 咨询 |
应用
A monoamine oxidase inhibitor1-Hydrazinophthalazine hydrochloride is a non-nucleoside analog that inhibits DNA methylation and reactivates the expression of tumor suppressor genes. It acts as a non-selective MAO-A/B inhibitor and semicarbazide sensitive amine oxidase inhibitor. Further, it serves as an antihypertensive. 备注
Incompatible with strong oxidizing agents. 基本信息 MDL
MFCD00135998 EINECS
206-151-0 分子式
C8H8N4?HCl 分子量
196.64 熔点
ca 275° dec. 灵敏度
Ambient temperatures. 形态
Powder 溶解性
Soluble in water. Slightly soluble in diethyl ether and alcohol. Beilstein
3568329 Merck
14,4763 GHS危害和防范说明 GHS符号
Hazard Statements
H301-H351-H361
Toxic if swallowed.Suspected of causing cancer.Suspected of damaging fertility or the unborn child. Precautionary Statements
P201-P280-P301+P310a-P308+P313-P405-P501a
Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Wear protective gloves/protective clothing/eye protection/face protection.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations. 安全信息 危险等级
6.1 包装组
III 危险类别
22-40-63
Harmful if swallowed.Limited evidence of a carcinogenic effect.Possible risk of harm to the unborn child. 安全等级
36/37
Wear suitable protective clothing and gloves. 欧盟危险品标志
 RTECS
TH9000000 TSCA
是 |
| H1120000 | | Hydralazine Hydrochloride | European Pharmacopoeia (EP) Reference Standard | 1277.32元/ ; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。 包装 Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C8H8N4 · HCl | | 分子量 | 196.64 | | MDL编号 | MFCD00135998 | | PubChem化学物质编号 | 329815153 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Cl[H].N\N=C1/N=NC=C2C=CC=CC12 | | InChI | 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-; | | InChI key | SECXUXOCDLQOBI-MKFZHGHUSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 - H315 - H319 - H335 | | 预防措施声明 | P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 | | 靶器官 | Respiratory system | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 |
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| H1753 | Sigma-Aldrich | Hydralazine Hydrochloride | | 869.57元/5 G; 1364.72元/10 G; 4209.84元/50 G; | 咨询 |
产品说明 应用 盐酸肼屈嗪已用于：
- 研究其作为血管扩张药，对大鼠幼鼠T细胞频率升高相关高血压的影响
- 研究其作为氨基脲敏感性胺氧化酶(SSAO)抑制剂，对心肌缺血再灌注(I/R)损伤的影响
- 研究其作为血管扩张药，对胰岛素分泌和葡萄糖耐受的影响
包装 5, 10, 50 g in poly bottle 生化/生理作用 盐酸肼屈嗪(Hydralazine)可用于治疗心力衰竭和高血压。
抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。 特点和优势 该化合物出现在受体分类和信号转导手册的多巴胺和去甲肾上腺素代谢页。想要浏览手册的其他页面，请点击此处。 基本信息 | 经验(实验)分子式 | C8H8N4 · HCl | | 分子量 | 196.64 | | EC 号 | 206-151-0 | | MDL编号 | MFCD00135998 | | PubChem化学物质编号 | 24278461 |
产品性质 | 生物来源 | synthetic (organic) | | 质量水平 | 100 | | 测定 | ≥99% (TLC) | | 形式 | powder | | mp | 273 ℃ | | 溶解性 | water: 50 mg/mL | | SMILES string | Cl[H].N\N=C1/N=NC=C2C=CC=CC12 | | InChI | 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-; | | InChI key | SECXUXOCDLQOBI-MKFZHGHUSA-N | | Gene Information | human ... MAOA(4128), MAOB(4129) |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 - H315 - H319 - H335 | | 预防措施声明 | P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 | | 靶器官 | Respiratory system | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
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| PHR3184 | Supelco | Hydralazine Hydrochloride | pharmaceutical secondary standard, certified reference material | 2317.45元/500 mg; | 咨询 |
产品说明 一般描述 Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards 生化/生理作用 抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。 分析说明 These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. 其他说明 This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. 附注 To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive. 基本信息 | 经验(实验)分子式 | C8H8N4 · HCl | | 分子量 | 196.64 | | MDL编号 | MFCD00135998 |
产品性质 | 等级 | certified reference material
pharmaceutical secondary standard | | CofA | current certificate can be downloaded | | 包装 | pkg of 500 mg | | application(s) | pharmaceutical | | 药典可追溯性 | traceable to USP 1313006 | | 储存温度 | 2-30℃ | | SMILES string | Cl[H].N\N=C1/N=NC=C2C=CC=CC12 | | InChI | 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-; | | InChI key | SECXUXOCDLQOBI-MKFZHGHUSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 - H315 - H319 - H335 | | 预防措施声明 | P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 | | 靶器官 | Respiratory system | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 1313006 | USP | Hydralazine Hydrochloride | United States Pharmacopeia (USP) Reference Standard | 3231.47元/200 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C8H8N4 · HCl | | 分子量 | 196.64 | | MDL编号 | MFCD00135998 | | PubChem化学物质编号 | 329750018 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | Cl[H].N\N=C1/N=NC=C2C=CC=CC12 | | InChI | 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-; | | InChI key | SECXUXOCDLQOBI-MKFZHGHUSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 - H315 - H319 - H335 | | 预防措施声明 | P301 + P330 + P331 + P310 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 | | 靶器官 | Respiratory system | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 236804 | Fluorochem | 1-Hydrazinylphthalazine hydrochloride | 95% | 836元/5g; 2596元/25g; | 咨询 |
基本信息 | CAS Number | 304-20-1 | | MDL Number | MFCD00135998 | | Melting Point | 273℃ |
安全信息 | 图形或危害标志 | | | 危险性说明 | H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H361: Suspected of damaging fertility or the unborn child ..
H362: May cause harm to breast-fed children.
| | 防范说明 | P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P263: Avoid contact during pregnancy/while nursing.
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P281: Use personal protective equipment as required.
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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