| CAS: | 303997-35-5 | |||
| 分子式: | C16H8ClF3N4S | |||
| 分子量: | 380.77 | |||
| 英文名称: |
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| 用途: | R-7050 是一种肿瘤坏死因子受体 (TNFR) 拮抗剂，对 TNFα 具有更高选择性。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||
| R798223 | MACKLIN | R-7050 | 10mM in DMSO | 706元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||
| R872225 | MACKLIN | R-7050 | 98% | 75元/1mg; 194元/5mg; 493元/25mg; 1421元/100mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
储存：-20℃ 状态：白色固体 | |||||||||||||||||||||||||||||||||||||||||||||
| SML1377 | Sigma-Aldrich | R-7050 | ≥95% (HPLC) | 1117.23元/5 MG; 4498.97元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
产品说明 包装 5, 25 mg in glass bottle 生化/生理作用 R-7050 is a cell-permeable TNF-α receptor antagonist that blocks TNF-α-induced binding of TNF-αRI with TNFαR-associated death domain protein and receptor interacting protein 1, blocking internalization of the TNFα-TNFαR complex. R-7050 was found to reduce neurovascular injury in a mouse model of hemorrhagic stroke. 基本信息
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| 654257 | Sigma-Aldrich | TNF-α Antagonist III, R-7050-CAS 303997-35-5-Calbiochem | The TNF-α Antagonist III, R-7050, also referenced under CAS 303997-35-5, controls the biological activity of TNF-α. | 2566.78元/10 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells. 包装 10 mg in Plastic ampoule 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 其他说明 Gururaja, T.L., et al. 2007. Chem. Biol.14, 1105. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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