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CAS: 2259-96-3
分子式: C14H16ClN3O4S2
分子量: 389.87
熔点: 234°C(lit.)
英文名称: 
4-benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-chloro-3-(5-norbornen-2-2h-2
2h-1,2,4-benzothiadiazine-7-sulfonamide, 3-bicyclo(2.2.1)hept-5-en-2-yl-6-chlor
o-3,4-dihydro-, 1,1-dioxide
4-benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(5-norbornen-2-2h-2
2,4-benzothiadiazine-3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-4-dihydro-2h- 1
7-sulfonamide 1,1-dioxide
35483
6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2h-1,2,4-benz othiadiazine-7-sulfonam
6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine 1,
6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1
anhydron
aquirel
cyclothiazide
doburil
lilly 35,483
mdi 193
renazide
valmiran
展开更多英文名
推荐供应商
货号品牌产品名称规格包装、参考价格
C868467MACKLIN环噻嗪95%,异构体混合物617元/25mg;   1750元/100mg;   咨询
储存:2-8°C
状态:白色到浅黄色粉末到晶体
C3392TCICyclothiazide (mixture of isomers)>95.0%(HPLC)590元/25MG;   1590元/100MG;   咨询

基本信息

纯度/分析方法>95.0%(HPLC)
分子式/分子量C14H16ClN3O4S2 = 389.87
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况加热
Reaxys-RN722843
PubChem物质ID354335513
Merck Index (14)2754
MDL编号MFCD00210192

技术规格

AppearanceWhite to Light yellow powder to crystal
Purity(HPLC)min. 95.0 %(total of isomer)
Elemental analysis(Nitrogen)10.20 to 11.20 %

物性(参考值)

熔点234 ℃
最大吸收波长273 nm

相关法规

RTECS#DK9610000
C9847Sigma-AldrichCyclothiazide1249.07元/10 MG;   3541.1元/25 MG;   咨询

产品说明

一般描述

Cyclothiazide is a benzothiadiazine, which has a similar structure to diazoxide.

应用

Cyclothiazide has been used as a α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) desensitization blocker to study the effects of γ2 on receptor desensitization.

包装

10 mg in poly bottle
25 mg in glass bottle

生化/生理作用

Blocks the rapid desensitization of the AMPA glutamate receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C14H16ClN3O4S2
分子量389.88
EC 号218-859-7
MDL编号MFCD00210192
PubChem化学物质编号24278350
NACRESNA.77

产品性质

质量水平200
创始人Eli Lilly
储存温度2-8℃
SMILES string[H][C@@]12CC(C3Nc4cc(Cl)c(cc4S(=O)(=O)N3)S(N)(=O)=O)[C@@]([H])(C1)C=C2
InChI1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)/t7-,8+,9?,14?/m0/s1
InChI keyBOCUKUHCLICSIY-QJWLJZLASA-N
Gene Informationhuman ... CA1(759), CA4(762), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
rat ... Gria1(50592)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
1159008USPCyclothiazideUnited States Pharmacopeia (USP) Reference Standard4191.89元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Blocks the rapid desensitization of the AMPA glutamate receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C14H16ClN3O4S2
分子量389.88
MDL编号MFCD00210192
PubChem化学物质编号329749494

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES string[H][C@@]12CC(C3Nc4cc(Cl)c(cc4S(=O)(=O)N3)S(N)(=O)=O)[C@@]([H])(C1)C=C2
InChI1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)/t7-,8+,9?,14?/m0/s1
InChI keyBOCUKUHCLICSIY-QJWLJZLASA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
M01473FluorochemCyclothiazide>98%1540元/10mg;   4972元/50mg;   咨询

基本信息

CAS Number2259-96-3
MDL NumberMFCD00210192
Melting Point227 - 228℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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