基本信息

技术规格

Technical Notes:

1.Highly active catalyst for hydrogenation of simple ketones giving high enantioselectivity when sterically unsymmetrical ketones such as acetophenone, heteroaryl ketones, benzophenones, cyclopropyl ketones, and cyclohexyl ketones are substrates. Ee's are enhanced with XyIBINAP relative to BINAP. The otherwise poorly bonded ketone is held in the transition state by hydrogen bonding to the protic bidentate amine.

2. Carbonyl groups are selectively reduced even when olefins exist in the s ame molecule.

3. In the presence of strong base, and catalyst, simple ketones, having substituents at the a-position, may be induced to undergo dynamic kinectic resolution during their hydrogenatio n toproduce , two chiral carbon centers in high yield.

References:

1. Angew Chem. Int. Ed.. 2001, 40, 40. (review article)

2.Org. Lott 2000, 2, 1749.

3.Org. Lott. 2000, 2, 659.

4.J. Am. Chem. Soc.. 1998. 120, 13529.

5.J. Am. Chem. Soc 2000, 122, 6510.

基本信息

分子量
1221.28

产品说明

应用

Catalyst for:

• Preparation of cyclometalated ruthenium 1,1-dianisyl-2-isopropyl-1,2-ethylenediamine complexes via asymmetric hydrogenation of ketones
• Enantioselective hydrogenation of an α-alkoxy substituted ketone with chiral ruthenium (phosphinoferrocenyl)oxazoline complexes
• Nonclassical asymmeteric hydrogen transfer between alcohols and carbonyl compounds
• Asymmetric hydrogenation of amino and heteroaromatic ketones

• Pharmacologically active substituted oxazolidinone used as NPC1L1 ligand for inhibition of cholesterol absorption

包装

50, 100 mg in amber glass bottle

法律信息

与 Takasago 合作销售，仅用于研究目的。日本注册号 041996, 2731377, 2935453，日本申请号19970359654

基本信息

产品性质