CAS 2062-78-4; 1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinon

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货号

品牌

产品名称

规格

包装、参考价格

P880633

MACKLIN

Pimozide

99%

388元/50mg;

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储存：2-8℃
状态：白色到灰白色粉末

P797656

MACKLIN

Pimozide

10mM in DMSO

308元/1ml;

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储存：-20°C
状态：液体

C24201

Alfa Aesar

Pimozide

8872元/1g;

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基本信息

Ref#
24201

分子式
C28H29F2N3O

分子量
74.14

GHS危害和防范说明

Hazard Statements
H302 H315 H318 H335

Precautionary Statements
P301+P330+P331 P302+P352 P332+P313 P305+P351+P338 P310 P304+P340 P280

P1793

Sigma-Aldrich

Pimozide

1274.2元/500 MG; 2377.5元/1 G;

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产品说明

包装

1 g in glass bottle
500 mg in glass bottle

生化/生理作用

D ₂ 多巴胺受体拮抗剂；与克隆的 5-HT ₇ 受体高亲和力结合；Ca ^{2 +} 通道拮抗剂；抗精神病药

特点和优势

该化合物出现在《受体分类和信号转导手册》的环核苷酸门控 (CNG) 和超极化激活环核苷酸门控 (HCN) 通道页。要浏览其他手册页，单击此处。
该化合物由 Teva 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。
该化合物是环核苷酸研究的特色产品。点击此处，发现更多特色环核苷酸产品。。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。

基本信息

经验(实验)分子式	C₂₈H₂₉F₂N₃O
分子量	461.55
EC 号	218-171-7
MDL编号	MFCD00055081
PubChem化学物质编号	24277923
NACRES	NA.77

产品性质

质量水平	200
溶解性	DMSO: 18 mg/mL(lit.) chloroform: 5 mg/mL H₂O: insoluble(lit.)
创始人	Teva
储存温度	2-8℃
SMILES string	Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5
InChI	1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChI key	YVUQSNJEYSNKRX-UHFFFAOYSA-N
Gene Information	human ... ABCB1(5243), CACNA1G(8913), CYP3A4(1576), DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356), HTR7(3363), KCNH1(3756), KCNH2(3757), OPRD1(4985) mouse ... Abcb1a(18671), Abcb1b(18669) rat ... Scnn1g(24768)

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

P1750000

Pimozide

European Pharmacopoeia (EP) Reference Standard

1414.22元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₈H₂₉F₂N₃O
分子量	461.55
MDL编号	MFCD00055081
PubChem化学物质编号	329820105
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5
InChI	1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChI key	YVUQSNJEYSNKRX-UHFFFAOYSA-N
Gene Information	human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1539508

USP

Pimozide

United States Pharmacopeia (USP) Reference Standard

3036.37元/200 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₈H₂₉F₂N₃O
分子量	461.55
MDL编号	MFCD00055081
PubChem化学物质编号	329750843
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5
InChI	1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChI key	YVUQSNJEYSNKRX-UHFFFAOYSA-N
Gene Information	human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

BP682

Pimozide

British Pharmacopoeia (BP) Reference Standard

2144.18元/100 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₈H₂₉F₂N₃O
分子量	461.55
MDL编号	MFCD00055081
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5
InChI	1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChI key	YVUQSNJEYSNKRX-UHFFFAOYSA-N
Gene Information	human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 + P330 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

573110

Sigma-Aldrich

STAT5 Inhibitor III, Pimozide-CAS 2062-78-4-Calbiochem

The STAT5 Inhibitor III, Pimozide, also referenced under CAS 2062-78-4, controls the biological activity of STAT5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphory

968.64元/100 MG;

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产品说明

一般描述

A cell-permeable and orally available diphenylbutylpiperidine class of psychotropic drug with antagonistic activity against DAT (dopamine transporter) as well as several postsynaptic receptors, including D₁, D₂, D₃, D₄, α₁-/α₂-adrenergic, and 5-HT_2A receptors. In addition to its antipsychotic property, Pimozide is shown to inhibit the constitutive STAT5 Tyr694 phosphorylation (5 to 10 µM for 3h) and transcription activity (5 µM for 18 h) in Bcr-Abl+ K562 and KU812 cultures, while exhibiting little activity against IFNα-stimulated STAT1 phosphorylation or LIF-stimulated STAT3 phosphorylation in K562 cells (10 µM 1 h pretreatment). The mechanism of STAT5 inhibition is currently unknown and Primozide is reported to exhibit little inhibitory activity against cellular Bcr-Abl autophosphorylation or the kinase activities of Abl1 (Wt & T315I), Hck, Lyn A/B, and Src (≤7%) in cell-free kinase assays. Shown to exhibit selective antiproliferative activity against K562, KU812, and primary bone marrow mononuclear cells from CML patients (by >80%; 10 µM for 48 h), but not peripheral blood mononuclear cells from healthy individuals, due to G0/G1 cell cycle arrest and apoptosis induction. Acts as a selective and non-competitive inhibitor of human USP1/UAF1 and USP7 activities (IC₅₀ = 2 and 47 µM, respectively) with no effect on UCH-L1 and UCH-L3 (IC₅₀ >500 µM).
A cell-permeable and orally available diphenylbutylpiperidine class of psychotropic drug with antagonistic activity against DAT (dopamine transporter) as well as several postsynaptic receptors, including D₁, D₂, D₃, D₄, α₁-/α₂-adrenergic, and 5-HT_2A receptors. In addition to its antipsychotic property, Pimozide is shown to inhibit the constitutive STAT5 Tyr694 phosphorylation (5 to 10 µM for 3h) and transcription activity (5 µM for 18 h) in Bcr-Abl+ K562 and KU812 cultures, while exhibiting little activity against IFNα-stimulated STAT1 phosphorylation or LIF-stimulated STAT3 phosphorylation in K562 cells (10 µM 1 h pretreatment). The mechanism of STAT5 inhibition is currently unknown and Primozide is reported to exhibit little inhibitory activity against cellular Bcr-Abl autophosphorylation or the kinase activities of Abl1 (Wt & T315I), Hck, Lyn A/B, and Src (≤7%) in cell-free kinase assays. Shown to exhibit selective antiproliferative activity against K562, KU812, and primary bone marrow mononuclear cells from CML patients (by >80%; 10 µM for 48 h), but not peripheral blood mononuclear cells from healthy individuals, due to G0/G1 cell cycle arrest and apoptosis induction.

包装

100 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions ar stable for up to 6 months at -20°C.

其他说明

Chen, J., et al. 2011. Chem. Biol18, 1390.
Nelson, E.A., et al. 2011. Blood117, 3421.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₈H₂₉F₂N₃O
分子量	461.55
MDL编号	MFCD00055081

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChI key	YVUQSNJEYSNKRX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable