| CAS: | 196497-48-0 | ||
| 分子式: | C18H39NO | ||
| 分子量: | 285.5 | ||
| 英文名称: |
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| 用途: | 1-Deoxysphinganine is an atypical sphingolipid that lacks the C1-hydroxyl group of canonical sphinganine. |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||
| D911981 | MACKLIN | 1-Deoxysphinganine (m18:0) | 98% | 3466元/1mg; | 咨询 | ||||||||||||||||||||||
储存：-20°C，密闭，干燥 | |||||||||||||||||||||||||||
| 860493P | Avanti | 1-deoxysphinganine | Avanti Polar Lipids 860493P, powder | 2636.64元/1 MG; 10532.9元/10 MG; | 咨询 | ||||||||||||||||||||||
产品说明 一般描述 1-deoxysphinganine is synthesized by the condensation of palmitic acid with alanine or glycine in the presence of enzyme serine palmitoyltransferase (SPT). It is metabolized to 1-deoxyceramides. 应用 1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8+ T cells. 生化/生理作用 1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine. 包装 5 mL Amber Glass Screw Cap Vial (860493P-1mg) 基本信息
产品性质
安全信息
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