| CAS: | 19309-14-9 | |||||
| 分子式: | C16H14O4 | |||||
| 分子量: | 270.28 | |||||
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| 用途: | Cardamonin是新颖的hTRPA1阳离子通道拮抗剂，IC50值为454 nM. |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||||||||||
| C860575 | MACKLIN | 小豆蔻明 | >98% | 117元/10mg; 392元/50mg; 647元/100mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||
储存：-20°C 状态：黄色粉末 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| C793260 | MACKLIN | 小豆蔻明 | 10mM in DMSO | 181元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| 835081 | J&K | Cardamonin | 98%, 来源于草豆蔻 | 72元/5MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||
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| 977906 | J&K | Cardamonin | 来源于草豆蔻, 有效含量≥90%, 可溯源至中检院标准品 | 228元/20MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||
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| 681672 | Sigma-Aldrich | Wnt/β-catenin Inhibitor, Cardamonin-CAS 19309-14-9-Calbiochem | The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer a | 2147.57元/2 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 Cardamonin, a known 2′,4′-dihydroxy-6′-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin. 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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| C8249 | Sigma-Aldrich | Cardamonin | ≥98% (HPLC) | 1989.21元/5 MG; 6418.84元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 应用 小豆蔻明已被用作高效液相色谱(HPLC)分析金合欢(acacia)蜂蜜样品中酚类化合物中的标准品。 包装 5, 25 mg in glass bottle 生化/生理作用 小豆蔻醚 (Cardamonin) 是一种来自豆蔻属(姜科植物)的植物。小豆蔻醚通过抑制 Wnt/β-连环蛋白 信号通路抑制黑素细胞色素沉着。小豆蔻醚通过蛋白酶体介导降解 β-连环蛋白(GSK-3β 非依赖性途径)抑制 Wnt/β-连环蛋白信号通路。研究表明，小豆蔻醚通过抑制 NF-kB 核转位和 Ik-Ba 磷酸化而具有抗炎活性。 其他说明 斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDFC8249.pdf中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。 基本信息
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| PHL80379 | Cardamomin | phyproof® Reference Substance | 4246.22元/10 MG; | 咨询 | |||||||||||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG 生化/生理作用 小豆蔻醚 (Cardamonin) 是一种来自豆蔻属(姜科植物)的植物。小豆蔻醚通过抑制 Wnt/β-连环蛋白 信号通路抑制黑素细胞色素沉着。小豆蔻醚通过蛋白酶体介导降解 β-连环蛋白(GSK-3β 非依赖性途径)抑制 Wnt/β-连环蛋白信号通路。研究表明，小豆蔻醚通过抑制 NF-kB 核转位和 Ik-Ba 磷酸化而具有抗炎活性。 法律信息 phyproof is a registered trademark of PhytoLab GmbH & Co. KG 基本信息
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