| CAS: | 18942-26-2 | |
| 分子式: | C41H32O27 | |
| 分子量: | 956.6799999999999 | |
| 英文名称: |
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| 用途: | Chebulinic acid 是一个天然的M. tuberculosis DNA gyrase抑制剂，也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||
| C880968 | MACKLIN | Chebulinic acid | ≥98% | 850元/5mg; 1199元/10mg; 3899元/50mg; | 咨询 | ||||||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||||||
| 150210 | J&K | Chebulinic acid | 98%, 一个天然的M. tuberculosis DNA gyrase抑制剂 | 4703元/5MG; | 咨询 | ||||||||||||||||||||||||||||||||
基本信息
产品描述 Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. 靶点（IC50 & Targe） target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3] 体外研究 In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3] 参考文献 [1]. Patel K et al. Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action. Comput Biol Chem. 2015 Dec;59 Pt A:37-47. [2]. Sivasankar S et al. Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acidprevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PLoS One. 2015 Mar 20 [3]. Mishra V et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine. 2013 Apr 15;20(6):506-11. | |||||||||||||||||||||||||||||||||||||
| SMB00271 | Sigma-Aldrich | Chebulinic acid | ≥85% (LC/MS-ELSD) | 4251.08元/1 MG; | 咨询 | ||||||||||||||||||||||||||||||||
产品说明 一般描述 Natural product derived from plant source. 生化/生理作用 Chebulinic acid is polyphenol that has shown antihypertensive, and anti-oxidant properties. Its antihypertensive effects may be due to decreased cardiac output from reduced left ventricular contraction. 基本信息
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| PHL80572 | Chebulinic acid | phyproof® Reference Substance | 12038.8元/10 MG; | 咨询 | |||||||||||||||||||||||||||||||||
产品说明 一般描述 This substance is supplied with certified chromatographic purity. The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG 法律信息 phyproof is a registered trademark of PhytoLab GmbH & Co. KG 基本信息
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| 40820 | Supelco | Chebulinic acid | analytical standard | 11407.5元/10 MG; | 咨询 | ||||||||||||||||||||||||||||||||
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