CAS 1835705-55-9; (s,r,s)-ahpc-c6-peg3-butyl chloride

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CAS:

1835705-55-9

分子式:

C₃₈H₅₉ClN₄O₇S

分子量:

751.42

英文名称:

(s,r,s)-ahpc-c₆-peg₃-butyl chloride

(s,r,s)-ahpc-6-2-2-6-cl

(2s,4r)-1-((s)-2-(tert-butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

用途:

(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation o

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S911139

MACKLIN

(S,R,S)-AHPC-C6-PEG3-C4-Cl (VH032-C6-PEG3-C4-Cl)

98%

6515元/100mg;

咨询

储存：-20°C，密闭，干燥

905380

Sigma-Aldrich

(S,R,S)-AHPC-C₆-PEG₃-butyl chloride

≥95%

4485.5元/50 MG;

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产品说明

应用

Protein degrader builiding block (S,R,S)-AHPC-C₆-PEG₃-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₃₈H₅₉ClN₄O₇S
分子量	751.42
MDL编号	MFCD31560478

产品性质

测定	≥95%
形式	solid
储存温度	2-8℃
SMILES string	ClCCCCCCOCCOCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O ClCCCCCCOCCOCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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