产品说明

一般描述

A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). Inhibits protein kinase A at much higher concentrations (K_i = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). May inhibit protein kinase A at much higher concentrations (K_i = 2 µM).

包装

1 mg in Plastic ampoule
250 μg in Plastic ampoule

生化/生理作用

Target K_i: 10 nM against protein kinase C
Primary Target
Protein kinase C
Product competes with ATP.
Cell permeable: no
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

其他说明

Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

产品说明

一般描述

GF 109203X可防止胶原蛋白触发的腺苷和三磷酸(ATP)分泌。它还可抑制胶原蛋白和α-凝血酶诱导的血小板聚集。它可作为糖原合成酶激酶-3(GSK-3)的抑制剂。GF 109203X也可作为一种抗炎剂。

应用

GF 109203X盐酸盐已被用于在人神经母细胞瘤衍生的kelly细胞中抑制蛋白激酶C。

包装

1 mg in glass bottle
250 μg in glass bottle

生化/生理作用

蛋白激酶C的抑制剂；GSK-3的有效抑制剂。

基本信息

产品性质

安全信息