CAS 169332-60-9; n-acetyl-asp-glu-val-asp-al

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货号

品牌

产品名称

规格

包装、参考价格

A860452

MACKLIN

Ac-DEVD-CHO

>98%

543元/1mg; 1740元/5mg; 6359元/25mg;

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储存：-20°C
状态：白色到灰白色粉末

A793309

MACKLIN

Ac-DEVD-CHO

10mM in Water

620元/1ml;

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储存：-20°C

235420

Sigma-Aldrich

Caspase-3 Inhibitor I-CAS 169332-60-9-Calbiochem

The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

1516.74元/1 MG; 6144.27元/5 MG;

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产品说明

一般描述

A very potent, specific, and reversible inhibitor of caspase-3 (IC₅₀ = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.
A specific and reversible inhibitor of CPP32/Apopain/Yama (IC₅₀ = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.

包装

1 mg in Glass bottle
5 mg in Plastic ampoule
Yes

生化/生理作用

Product does not compete with ATP.
Reversible: yes
Target IC₅₀: 200 pM against caspase-3
Cell permeable: no
Primary Target
Capase-3, capase-6, capase-7, capase-8, capase-10

警告

Toxicity: Standard Handling (A)

序列

Ac-Asp-Glu-Val-Asp-CHO

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature376, 37.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₀H₃₀N₄O₁₁
分子量	502.47
MDL编号	MFCD00671412

产品性质

质量水平	100
测定	≥90% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	DMSO: 5 mg/mL water: soluble
运输	ambient
储存温度	−20℃
InChI	1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1
InChI key	UMBVAPCONCILTL-MRHIQRDNSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

A0835

Sigma-Aldrich

N-Acetyl-Asp-Glu-Val-Asp-al

≥95%, powder

1983.64元/1 MG; 6881.59元/5 MG;

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产品说明

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-al

一般描述

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 是一种具有N端乙酰化和C端醛共轭的四肽。

应用

N-Acetyl-Asp-Glu-Val-Asp-al已在肌肉样品、平滑肌细胞和Jurkat T细胞中被用作半胱氨酸蛋白酶抑制剂。

生化/生理作用

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 可通过其半胱氨酸蛋白酶抑制剂的功能性有助于顿抑心肌的恢复。
IL-1β的可逆性抑制剂；转化酶(ICE)；通过凋亡蛋白(caspase 3)抑制聚(ADP-核糖)聚合酶的切割。

基本信息

经验(实验)分子式	C₂₀H₃₀N₄O₁₁
分子量	502.47
MDL编号	MFCD00671412
PubChem化学物质编号	24890193
NACRES	NA.32

产品性质

质量水平	100
生物来源	synthetic
测定	≥95%
形式	powder
颜色	white
溶解性	H₂O: 1 mg/mL
储存温度	−20℃
SMILES string	[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C
InChI	1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)
InChI key	UMBVAPCONCILTL-UHFFFAOYSA-N
Gene Information	human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)