CAS 16858-02-9; n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine

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货号

品牌

产品名称

规格

包装、参考价格

N823736

MACKLIN

N,N,N',N'-四(2-吡啶甲基)乙二胺

97%

210元/100mg; 439元/250mg; 1068元/1g; 4389元/5g; 16061元/25g;

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储存：室温
状态：淡黄色-灰黄色红色晶体-粉末
折射率：1.631

N793790

MACKLIN

N, N, N', N'-四(2-吡啶甲基)乙二胺

10mM in DMSO

528元/1ml;

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储存：-20°C

T1487

TCI

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine

>97.0%(T)

1895元/1G; 6245元/5G;

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基本信息

纯度/分析方法	>97.0%(T)
分子式/分子量	C₂₆H₂₈N₆ = 424.55
外观与形状(20℃)	固体
Reaxys-RN	4211982
PubChem物质ID	87577249
MDL编号	MFCD00036918

技术规格

Appearance	Light yellow to Brown powder to crystal
Purity(Nonaqueous Titration)	min. 97.0 %

物性(参考值)

熔点	112 ℃(dec.)
溶解性(可溶于)	甲醇

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

293756

J&K

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine

98%

2039元/100MG; 5021元/500MG;

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基本信息

分子式	C₂₆H₂₈N₆
分子量	424.55
熔点	110-114
MDL编码	MFCD00036918
Beilstein	4211982

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	3
TSCA	否

J64206

Alfa Aesar

N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine

3069元/100mg; 7667元/300mg;

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应用
A cell permeable and extremely high-affinity chelator of heavy metals

基本信息

MDL
MFCD00036918

分子式
C₂₆H₂₈N₆

分子量
424.54

熔点
110-112°

灵敏度
Keep Cold.

形态
Powder

Beilstein
4211982

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

TSCA
否

616394

Millipore

TPEN-CAS 16858-02-9-Calbiochem

2245.49元/100 MG;

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产品说明

一般描述

Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca²⁺ levels in cells. Also useful in extracting Aβ amyloid deposits from Alzheimer’s disease brain tissue. Has extremely high affinity for heavy metals but low affinity for Ca²⁺ and Mg²⁺. Induces DNA fragmentation when chelated with Zn²⁺ and induces apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2 (Cat. No. 551826).
Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca²⁺ in cells. Has an extremely high affinity for heavy metals but a low affinity for Ca²⁺ and Mg²⁺. Induces DNA fragmentation when chelated with Zn²⁺ and causes apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2. Shown to be useful in extracting Aβ depostis from Alzheimer′s disease brain tissue.

包装

100 mg in Plastic ampoule

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.

其他说明

Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995. Biochem. J.312, 919.
Jiang, S., et al. 1995. Lab. Invest.73, 111.
Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon33, 539.
McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992. J. Biol. Chem.267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol.138, 593.
Raspe, E., et al. 1989. Eur. J. Pharmacol.163, 345.
Arslan, L.P., et al. 1985. J. Biol. Chem.260, 2719.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₆H₂₈N₆
分子量	424.54
MDL编号	MFCD00036918

产品性质

质量水平	100
测定	≥97% (titration)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	tan
溶解性	ethanol: 10 mg/mL 0.1 M phosphate pH 7.0: 25 μM DMSO: soluble
运输	ambient
储存温度	15-25℃
InChI	1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
InChI key	CVRXLMUYFMERMJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

P4413

Sigma-Aldrich

N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine

1181.2元/50 MG; 1714.02元/100 MG;

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产品说明

应用

N,N,N′,N′-四(2-吡啶甲基)乙二胺用于：

处理人胚肾(HEK293T)细胞，评估其对Jembrana病病毒(JDV)病毒感染因子(Vif)功能的作用
在P19胚胎癌细胞中，螯合细胞凋亡过程中释放的锌离子
评估其对细胞慢病毒Vpx感染人单核THP-1细胞的作用

包装

50, 100 mg in poly bottle

生化/生理作用

N,N,N′,N′-四(2-吡啶甲基)乙二胺(TPEN)通过抑制一氧化氮信号传导和Zn²⁺ 信号传导，引起人急性早幼粒细胞 NB4细胞中的促凋亡作用。在锌预处理的小胶质细胞中，TPEN抑制白介素6分泌和一氧化氮合酶(iNOS)mRNA表达。通过激活人结肠癌细胞中的ATM(毛细血管扩张性共济失调突变)和ATR(ATM-Rad3相关)信号传导，诱导DNA结构受损。
TPEN是一种可透过膜的锌螯合剂；可降低细胞内锌水平并诱导细胞凋亡(即细胞收缩和凋亡小体的形成、DNA片段化和形成典型的DNA梯状带)。

特点和优势

该化合物是细胞凋亡研究的推荐产品。点击这里发现更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。

基本信息

经验(实验)分子式	C₂₆H₂₈N₆
分子量	424.54
Beilstein	4211982
MDL编号	MFCD00036918
PubChem化学物质编号	24898538
NACRES	NA.77

产品性质

质量水平	100
SMILES string	C(CN(Cc1ccccn1)Cc2ccccn2)N(Cc3ccccn3)Cc4ccccn4
InChI	1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
InChI key	CVRXLMUYFMERMJ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves